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HomeProduct name listPRUNASIN

PRUNASIN

Synonym(s):D-Mandelonitrile β-D-glucoside

  • CAS NO.:99-18-3
  • Empirical Formula: C14H17NO6
  • Molecular Weight: 295.29
  • MDL number: MFCD00049232
  • EINECS: 202-738-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-26 21:18:56
PRUNASIN Structural

What is PRUNASIN?

Description

(R)-Prunasin is a cyanogenic glucoside that is the precursor to amygdalin, a bitter component found in species of the genera Prunus and Olinia. It can be degraded to hydrogen cyanide, glucose, and benzaldehyde by the action of prunasin hydrolase and mandelonitrile lyase and possesses inhibitory effects on plant growth. (R)-Prunasin reportedly inhibits rat DNA polymerase β, which performs base excision repair required for DNA maintenance and replication, with an IC50 value of 98 μM.

Chemical properties

White Solid

The Uses of PRUNASIN

Used in the synthesis of cyanogen glycoside. A component of antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair

Definition

ChEBI: (R)-prunasin is a prunasin.

Enzyme inhibitor

This cyanogenic glucoside (FW = 295.29 g/mol; CAS 99-18-3), also known as D(R)-mandelonitrile-b-D-glucoside, is readily obtained from amygdalin and is found in the pits of Prunus serotina. Prunasin is soluble in water and will give rise to prulaurasin (i.e., the diastereoisomeric mixture of DL(RS)- mandelonitrile-b-D-glucoside [i.e., prunasin and sambunigrin]). Target(s): DNA-directed DNA polymerase; DNA polymerase b; and a,a trehalase.

Properties of PRUNASIN

Melting point: 138-148°C
Boiling point: 527.0±50.0 °C(Predicted)
Density  1.45±0.1 g/cm3(Predicted)
storage temp.  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  Powder
pka 12.71±0.70(Predicted)
color  White to off-white
Stability: Hygroscopic

Safety information for PRUNASIN

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H301:Acute toxicity,oral
H360:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.

Computed Descriptors for PRUNASIN

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