PROXYPHYLLINE
Synonym(s):(1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine);7-(β-Hydroxypropyl)theophylline;Proxyphylline
- CAS NO.:603-00-9
- Empirical Formula: C10H14N4O3
- Molecular Weight: 238.24
- MDL number: MFCD00022833
- EINECS: 210-028-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is PROXYPHYLLINE?
Chemical properties
White Solid
The Uses of PROXYPHYLLINE
A metabolite of Theophylline in human plasma.
What are the applications of Application
Proxyphylline is a metabolite of Theophylline
Definition
ChEBI: Proxyphylline is an oxopurine.
Biological Activity
ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.
in vitro
previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].
in vivo
in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].
Purification Methods
Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]
References
[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55.
Properties of PROXYPHYLLINE
Melting point: | 134-136°C |
Boiling point: | 487.2±51.0 °C(Predicted) |
Density | 1.46±0.1 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Solution S is clear (2.2.1) and colourless (2.2.2, Method II). |
form | neat |
pka | 14.55±0.20(Predicted) |
form | Solid |
color | White to Off-White |
Water Solubility | 285.7g/L(temperature not stated) |
Merck | 14,7905 |
CAS DataBase Reference | 603-00-9(CAS DataBase Reference) |
NIST Chemistry Reference | Proxyphylline(603-00-9) |
Safety information for PROXYPHYLLINE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for PROXYPHYLLINE
Abamectin manufacturer
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