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HomeProduct name listPROXYPHYLLINE

PROXYPHYLLINE

Synonym(s):(1,3-Dimethyl-7-[2-hydroxypropyl]-2,6-dioxopurine);7-(β-Hydroxypropyl)theophylline;Proxyphylline

  • CAS NO.:603-00-9
  • Empirical Formula: C10H14N4O3
  • Molecular Weight: 238.24
  • MDL number: MFCD00022833
  • EINECS: 210-028-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 16:48:35
PROXYPHYLLINE Structural

What is PROXYPHYLLINE?

Chemical properties

White Solid

The Uses of PROXYPHYLLINE

A metabolite of Theophylline in human plasma.

What are the applications of Application

Proxyphylline is a metabolite of Theophylline

Definition

ChEBI: Proxyphylline is an oxopurine.

Biological Activity

ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors.

in vitro

previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1].

in vivo

in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2].

Purification Methods

Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.]

References

[1] u. schwabe, d. ukena and m. j. lohse. xanthine derivatives as antagonists at a1 and a2 adenosine receptors. naunyn-schmiedeberg's arch.pharmacol. 330,212-221 (1985).
[2] s. bang, y. s. kim and s. r. jeong. anti-allodynic effect of theoesberiven f in a vincristine-induced neuropathy model. exp. ther. med. 12(2), 799-803 (2016).
[3] selvig k. pharmacokinetics of proxyphylline in adults after intravenous and oral administration. eur j clin pharmacol. 1981 jan;19(2):149-55.

Properties of PROXYPHYLLINE

Melting point: 134-136°C
Boiling point: 487.2±51.0 °C(Predicted)
Density  1.46±0.1 g/cm3(Predicted)
storage temp.  Inert atmosphere,Room Temperature
solubility  Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
form  neat
pka 14.55±0.20(Predicted)
form  Solid
color  White to Off-White
Water Solubility  285.7g/L(temperature not stated)
Merck  14,7905
CAS DataBase Reference 603-00-9(CAS DataBase Reference)
NIST Chemistry Reference Proxyphylline(603-00-9)

Safety information for PROXYPHYLLINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for PROXYPHYLLINE

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