PROTOPORPHYRINATO ZINC
Synonym(s):Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem;ZnPP-9
- CAS NO.:15442-64-5
- Empirical Formula: C34H31N4O4Zn-
- Molecular Weight: 625.03
- MDL number: MFCD00011612
- EINECS: 239-455-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-18 17:01:59
What is PROTOPORPHYRINATO ZINC?
The Uses of PROTOPORPHYRINATO ZINC
Zinc Protoporphyrin is a metabolite formed during biosynthesis and is used to evaluate iron nutrition and metabolism.
What are the applications of Application
Zinc Protoporphyrin-9 is a potent, selective inhibitor of heme oxygenase, GCS, NOS1, NOS2, and NOS3.
General Description
A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50 = 800 nM, 4 μM, and 5 μM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.
Biological Activity
Inhibitor of heme oxygenase, which generates the putative neurotransmitter CO.
Biochem/physiol Actions
Primary Targetheme oxygenase
Properties of PROTOPORPHYRINATO ZINC
RTECS | ZG9210300 |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
form | Crystalline |
color | Dark red to purple |
Water Solubility | Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide. |
Stability: | Hygroscopic |
EPA Substance Registry System | Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5) |
Safety information for PROTOPORPHYRINATO ZINC
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PROTOPORPHYRINATO ZINC
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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