PROTOPORPHYRINATO ZINC

Synonym(s):Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem;ZnPP-9

CAS NO.：15442-64-5
Empirical Formula: C34H31N4O4Zn-
Molecular Weight: 625.03
MDL number: MFCD00011612
EINECS: 239-455-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is PROTOPORPHYRINATO ZINC?

The Uses of PROTOPORPHYRINATO ZINC

Zinc Protoporphyrin is a metabolite formed during biosynthesis and is used to evaluate iron nutrition and metabolism.

What are the applications of Application

Zinc Protoporphyrin-9 is a potent, selective inhibitor of heme oxygenase, GCS, NOS1, NOS2, and NOS3.

General Description

A potent and selective inhibitor of heme oxygenase, the enzyme which generates carbon monoxide (CO) and biliverdin. Inhibits soluble guanylyl cyclase and produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀ = 800 nM, 4 μM, and 5 μM for nNOS, iNOS, and eNOS, respectively). Inhibits relaxation induced by acetylcholine, ANP, and VIP in isolated rat aorta. Blocks interleukin-1 and prevents induction of long-term potentiation. Also useful as an indicator of iron-deficient erythropoiesis. Does not cross the blood-brain barrier.

Biological Activity

Inhibitor of heme oxygenase, which generates the putative neurotransmitter CO.

Biochem/physiol Actions

Primary Targetheme oxygenase

Properties of PROTOPORPHYRINATO ZINC

RTECS	ZG9210300
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form	Crystalline
color	Dark red to purple
Water Solubility	Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide.
Stability:	Hygroscopic
EPA Substance Registry System	Zincate(2-), [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-.kappa.N21,.kappa.N22,.kappa.N23,.kappa.N24]-, dihydrogen, (SP-4-2)- (15442-64-5)

Safety information for PROTOPORPHYRINATO ZINC

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.