PROTAC FLT-3 degrader 1
- CAS NO.:2230826-81-8
- Empirical Formula: C52H61N9O9S2
- Molecular Weight: 1020.23
- MDL number: MFCD32705099
- Update Date: 2024-07-02 08:55:42
What is PROTAC FLT-3 degrader 1?
Biological Activity
PROTAC FLT-3 degrader 1 is a von Hippel-Lindau-based PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction[1].
References
[1]. Burslem GM, et al. Enhancing Antiproliferative Activity and Selectivity of a FLT-3 Inhibitor by Proteolysis Targeting Chimera Conversion. J Am Chem Soc. 2018 Dec 5;140(48):16428-16432.
Properties of PROTAC FLT-3 degrader 1
Density | 1.38±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO : 150 mg/mL (147.03 mM; Need ultrasonic) |
form | Solid |
pka | 12.59±0.70(Predicted) |
color | White to light yellow |
Safety information for PROTAC FLT-3 degrader 1
Computed Descriptors for PROTAC FLT-3 degrader 1
New Products
Tert-butyl bis(2-chloroethyl)carbamate 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid DIETHYL AMINOMALONATE HYDROCHLORIDE 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) N-METHYL INDAZOLE-3-CARBOXYLIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
PROTAC RIPK degrader-2
PROTAC BET degrader-2
Protein degrader 1 (TFA)
PROTAC CRBN Degrader-1
PROTAC FAK degrader 1
PROTAC K-Ras Degrader-1
PROTAC ERRα Degrader-1
PROTAC BRD9 Degrader-1
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