PROTAC FAK degrader 1
- CAS NO.：2301916-69-6
- Empirical Formula: C47H56F3N9O8S2
- Molecular Weight: 996.13
- Update Date: 2024-07-02 08:54:58
What is PROTAC FAK degrader 1?
Description
PROTAC FAK degrader 1 is a selective and potent focal adhesion kinase (Fak) degrader with an IC50 of 6.5 nM, DC50 of 3 nM[1]. IC50: 6.5 nM (Focal adhesion kinase)DC50: 3 nM (Focal adhesion kinase)[1]
References
[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026.
Properties of PROTAC FAK degrader 1
| Density | 1.368±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 200 mg/mL (200.78 mM) |
| pka | 14.07±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for PROTAC FAK degrader 1
Computed Descriptors for PROTAC FAK degrader 1
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