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HomeProduct name listPROTAC ER Degrader-4

PROTAC ER Degrader-4

  • CAS NO.:2361114-15-8
  • Empirical Formula: C53H67F3N6O8S
  • Molecular Weight: 1005.19
  • MDL number: MFCD34469813
  • Update Date: 2024-07-02 08:55:04

What is PROTAC ER Degrader-4?

Biological Activity

PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC50 of 0.3 nM[1]. PROTAC ER Degrader-4 shows equal to 100% ER degradation at 0.3 μM in the MCF-7 ER degradation cellular assay[1].

References

[1]. Bin Yang, et al. Compounds and their use in treating cancer. WO2019123367A1.

Properties of PROTAC ER Degrader-4

Boiling point: 1038.9±65.0 °C(Predicted)
Density  1.254±0.06 g/cm3(Predicted)
pka 13.54±0.46(Predicted)
form  Solid
color  Light yellow to yellow

Safety information for PROTAC ER Degrader-4

Computed Descriptors for PROTAC ER Degrader-4

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