Propargyl-PEG3-amine
- CAS NO.：932741-18-9
- Empirical Formula: C9H15N3O3
- Molecular Weight: 213.24
- MDL number: MFCD20720810
- Update Date: 2024-03-26 17:16:27
What is Propargyl-PEG3-amine?
Biological Activity
Propargyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Safety information for Propargyl-PEG3-amine
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