PROCYANIDIN C1
Synonym(s):Cinnamtannin A1;Proanthocyanidin C1;Procyanidol C1
- CAS NO.:37064-30-5
- Empirical Formula: C45H38O18
- Molecular Weight: 866.77
- MDL number: MFCD01682743
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-15 19:00:21
What is PROCYANIDIN C1?
Description
Procyanidin C1 is a polyphenol flavonoid trimer of (–)-epicatechin that has HIV-related and antioxidant activities. It activates latent HIV-1 provirus in JLR2 cells when used at concentrations ranging from 12.5 to 50 μM and increases NF-κB-dependent transcriptional activity in Jurkat T cells. Procyanidin C1 also scavenges 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 3.2 μg/ml) and inhibits the activity of α-glucosidase (IC50 = 3.8 μg/ml) and 15-lipoxygenase (15-LO; IC50 = 57.6 μg/ml). Procyanidin C1 (10 μg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.
Definition
ChEBI: Procyanidin C1 is a proanthocyanidin consisting of three (-)-epicatechin units joined by two successive (4beta->8)-linkages. It has a role as a metabolite, an anti-inflammatory agent, an antioxidant, a lipoxygenase inhibitor, an EC 1.17.3.2 (xanthine oxidase) inhibitor and an EC 3.2.1.20 (alpha-glucosidase) inhibitor. It is a hydroxyflavan, a proanthocyanidin and a polyphenol. It is functionally related to a (-)-epicatechin.
Properties of PROCYANIDIN C1
Density | 1.747±0.06 g/cm3( 20 ºC : 760 Torr) |
storage temp. | -20°C |
solubility | Soluble in methan |
form | neat |
pka | 9.19±0.70(Predicted) |
form | Solid |
color | Beige-brown |
Safety information for PROCYANIDIN C1
Computed Descriptors for PROCYANIDIN C1
New Products
2,2-diethoxyethanethioamide Tubulysin E Tubulysin F (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin G CYCLOBUTYLAMINE HYDROCHLORIDE 2H-Pyran, 4-ethynyltetrahydro- 4-FLUOROPIPERIDINE HYDROCHLORIDE 2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 3,6-Dihydro-2H-pyran-4-carbonitrile N-(2-methoxy-5-nitrophenyl)acetamide 5-Nitrobarbituric acid N-[2-(Acetylthio)-1-oxobutyl]glycine ethyl ester methyl 2-bromobenzoate 4-chloro-2-hydroxy-5-nitropyridine 5-Bromo-2-chloroisonicotinic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid (2S)-3-Methyl-2-(methylamino)-1-butanol Simvastatin EP Impurity I Sildenafil Chlorosulfone Impurity / Sildenafil Chlorosulfone / Sildenafil Chlorosulfonyl Impurity BETAMETHASONE EP IMPURITY CRelated products of tetrahydrofuran
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