Procyanidin B1
Synonym(s):(−)-Epicatechin (4β-8)-(+)-catechin;cis,trans′′-4,8′′-Bi-(3,3′,4′,5,7-Pentahydroxyflavane);Proanthocyanidin B1
- CAS NO.:20315-25-7
- Empirical Formula: C30H26O12
- Molecular Weight: 578.52
- MDL number: MFCD01861512
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:06
What is Procyanidin B1?
Description
Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin and (−)-epicatechin . It inhibits hepatitis C virus RNA replication (EC50 = 72 μM), while (+)-catechin and (−)-epicatechin do not, up to concentrations of 200 μM. Procyanidin B1 (10 μg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells. It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.
The Uses of Procyanidin B1
Procyanidins B1 is a B type proanthocyanidins found in ceylon cinnamon and is known to exhibit anti-inflammatory effects.
What are the applications of Application
Procyanidin B1 is a flavanol used in Hepatitis C virus research
Definition
ChEBI: Procyanidin B1 is a proanthocyanidin consisting of (-)-epicatechin and (+)-catechin units joined by a bond between positions 4 and 8' respectively in a beta-configuration.. Procyanidin B1 can be found in Cinnamomum verum (Ceylon cinnamon, in the rind, bark or cortex), in Uncaria guianensis (cat's claw, in the root), and in Vitis vinifera (common grape vine, in the leaf) or in peach. It has a role as a metabolite, an EC 3.4.21.5 (thrombin) inhibitor and an anti-inflammatory agent. It is a hydroxyflavan, a proanthocyanidin, a biflavonoid and a polyphenol. It is functionally related to a (-)-epicatechin and a (+)-catechin.
Properties of Procyanidin B1
Melting point: | 231~232℃ |
Boiling point: | 955.3±65.0 °C(Predicted) |
Density | 1.705±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,2-8°C |
solubility | Acetone (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly) |
pka | 9.29±0.60(Predicted) |
form | neat |
form | Solid |
color | Pale Brown |
Safety information for Procyanidin B1
Computed Descriptors for Procyanidin B1
InChIKey | XFZJEEAOWLFHDH-UKWJTHFESA-N |
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