10-METHYLPHENOTHIAZINE
Synonym(s):N -Methylphenothiazine;10-Methyl-10H -phenothiazine
- CAS NO.：1207-72-3
- Empirical Formula: C13H11NS
- Molecular Weight: 213.3
- MDL number: MFCD00041836
- EINECS: 214-896-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:34
What is 10-METHYLPHENOTHIAZINE?
Chemical properties
slightly yellow to pale green crystalline powder
The Uses of 10-METHYLPHENOTHIAZINE
They are used in pharmaceutical manufacturing especially antipsychotic drugs. Also used as a stabilizer against polymerization of acrylates.
Definition
ChEBI: 10-methylphenothiazine is a member of phenothiazines.
Purification Methods
Recrystallise it (three times) from EtOH to give the -form (prisms). Recrystallisation from EtOH/*benzene gives the .-form (needles). It has also been purified by vacuum sublimation and is carefulmax 255nm (log 4.60) (pH 6.3) and 255nm in hexane. [Cymerman-Craig & Warburton Aust J Chem 9 294 1956, Beilstein 27 II 33, 27 III/IV 1215.]
Properties of 10-METHYLPHENOTHIAZINE
| Melting point: | 99-101 °C (lit.) |
| Boiling point: | 341.6±12.0 °C(Predicted) |
| Density | 1.1168 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 0.56±0.20(Predicted) |
| color | White to Light yellow |
| Water Solubility | Insoluble in water. |
| λmax | 310nm(CHCl3)(lit.) |
| CAS DataBase Reference | 1207-72-3(CAS DataBase Reference) |
| EPA Substance Registry System | 10H-Phenothiazine, 10-methyl- (1207-72-3) |
Safety information for 10-METHYLPHENOTHIAZINE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 10-METHYLPHENOTHIAZINE
| InChIKey | QXBUYALKJGBACG-UHFFFAOYSA-N |
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