PROCATEROL HYDROCHLORIDE

Description

Procaterol is an agonist of β₂-adrenergic receptors (β₂-ARs). It binds to (K_d = 46 pM), and is selective for, β₂-ARs over β₁-ARs (K_d = 4,000 pM). Procaterol binds more potently to β₂-ARs in isolated guinea pig lung than to β₁-ARs in isolated guinea pig cardiac ventricle in the presence (IC_50s = 175 and 1,660 nM, respectively) and absence of GTP (; IC₅₀s = 55.1 and 1,660 nM, respectively). It inhibits contractions induced by acetylcholine in isolated guinea pig trachea (EC₅₀ = 10.5 nM). In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 μg/ml.

The Uses of PROCATEROL HYDROCHLORIDE

Procaterol Hydrochloride is a short-acting pulmonary β2-agonist for asthma treatment.

The Uses of PROCATEROL HYDROCHLORIDE

adrenergic agonists

What are the applications of Application

Procaterol hydrochloride is a very potent and specific β2 agonist

General Description

Procaterol is used to prevent lung fibroblast migration. It has anti-inflammatory properties. It can block type 2 T helper (Th2)-related chemokine production in human monocytes and bronchial epithelial cells.

Biological Activity

Specific and very potent β 2 agonist.

Biochem/physiol Actions

β2-adrenoceptor agonist; bronchodilator.

storage

Store at RT