Polyinosinic-polycytidylic acid sodium salt
Synonym(s):Poly (I:C);Poly I • poly C, Na;Poly(I) ? Poly(C);Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded - CAS 42424-50-0 - Calbiochem
- CAS NO.：42424-50-0
- Empirical Formula: C19H27N7O16P2
- Molecular Weight: 671.41
- MDL number: MFCD00131957
- EINECS: 1308068-626-2
- Update Date: 2024-11-13 18:13:23
What is Polyinosinic-polycytidylic acid sodium salt?
The Uses of Polyinosinic-polycytidylic acid sodium salt
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
The Uses of Polyinosinic-polycytidylic acid sodium salt
Polyinosinic Acid & Polycytidylic Acid Sodium Salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.
What are the applications of Application
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded is a TLR3 (Toll-like receptor 3) agonist
Biological Activity
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.
storage
Store at -20°C
Properties of Polyinosinic-polycytidylic acid sodium salt
| storage temp. | −20°C |
| solubility | H2O: soluble10mg/mL |
| form | lyophilized powder |
| color | White to off-white |
| Water Solubility | Water : 10 mg/mL (Need ultrasonic and warming) |
Safety information for Polyinosinic-polycytidylic acid sodium salt
Computed Descriptors for Polyinosinic-polycytidylic acid sodium salt
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