Polyinosinic-polycytidylic acid sodium salt
Synonym(s):Poly (I:C);Poly I • poly C, Na;Poly(I) ? Poly(C);Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded - CAS 42424-50-0 - Calbiochem
- CAS NO.:42424-50-0
- Empirical Formula: C19H27N7O16P2
- Molecular Weight: 671.41
- MDL number: MFCD00131957
- EINECS: 1308068-626-2
- Update Date: 2024-09-10 19:09:04
What is Polyinosinic-polycytidylic acid sodium salt?
The Uses of Polyinosinic-polycytidylic acid sodium salt
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
The Uses of Polyinosinic-polycytidylic acid sodium salt
Polyinosinic Acid & Polycytidylic Acid Sodium Salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.
What are the applications of Application
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded is a TLR3 (Toll-like receptor 3) agonist
Biological Activity
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.
storage
Store at -20°C
Properties of Polyinosinic-polycytidylic acid sodium salt
storage temp. | −20°C |
solubility | H2O: soluble10mg/mL |
form | lyophilized powder |
color | White to off-white |
Water Solubility | Water : 10 mg/mL (Need ultrasonic and warming) |
Safety information for Polyinosinic-polycytidylic acid sodium salt
Computed Descriptors for Polyinosinic-polycytidylic acid sodium salt
New Products
Tubulysin D Tubulysin C Tubulysin I Tubulysin F Tubulysin B Potassium HMDS (1.0 M in THF) 2H-Pyran, 4-ethynyltetrahydro- 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4,4-DIFLUOROPIPERIDINE 2,2-Difluoropropanol tetrahydro-4-methyl-2H-pyran 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateRelated products of tetrahydrofuran
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