Polyinosinic-polycytidylic acid sodium salt
Synonym(s):Poly (I:C);Poly I • poly C, Na;Poly(I) ? Poly(C);Polyinosinic Acid • Polycytidylic Acid, Sodium Salt, Double-Stranded - CAS 42424-50-0 - Calbiochem
- CAS NO.:42424-50-0
- Empirical Formula: C19H27N7O16P2
- Molecular Weight: 671.41
- MDL number: MFCD00131957
- EINECS: 1308068-626-2
- Update Date: 2024-11-19 20:33:22
What is Polyinosinic-polycytidylic acid sodium salt?
The Uses of Polyinosinic-polycytidylic acid sodium salt
TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. Polyinosinic–polycytidylic acid sodium salt is a double-stranded homopolymer used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.
The Uses of Polyinosinic-polycytidylic acid sodium salt
Polyinosinic Acid & Polycytidylic Acid Sodium Salt (double-stranded) is a TLR3 (Toll-like receptor 3) agonist.
What are the applications of Application
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded is a TLR3 (Toll-like receptor 3) agonist
Biological Activity
Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis.
storage
Store at -20°C
Properties of Polyinosinic-polycytidylic acid sodium salt
storage temp. | −20°C |
solubility | H2O: soluble10mg/mL |
form | lyophilized powder |
color | White to off-white |
Water Solubility | Water : 10 mg/mL (Need ultrasonic and warming) |
Safety information for Polyinosinic-polycytidylic acid sodium salt
Computed Descriptors for Polyinosinic-polycytidylic acid sodium salt
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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