POBN

Synonym(s):N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide;N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide;POBN

CAS NO.：66893-81-0
Empirical Formula: C10H14N2O2
Molecular Weight: 194.23
MDL number: MFCD00041022
EINECS: 266-512-3
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:16

What is POBN?

Chemical properties

white to pale yellow crystalline powder

The Uses of POBN

Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.

The Uses of POBN

POBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide.

What are the applications of Application

POBN is a cell permeable hydrophilic spin trap

Properties of POBN

Melting point:	183-185 °C(lit.)
Boiling point:	330.68°C (rough estimate)
Density	1.1444 (rough estimate)
refractive index	1.5000 (estimate)
storage temp.	room temp
solubility	water: soluble10mg/mL, clear, colorless to faintly yellow
form	White to off-white or colorless crystalline solid.
pka	0.76±0.53(Predicted)
color	White to Light yellow
BRN	1453764