POBN
Synonym(s):N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide;N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide;POBN
- CAS NO.：66893-81-0
- Empirical Formula: C10H14N2O2
- Molecular Weight: 194.23
- MDL number: MFCD00041022
- EINECS: 266-512-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is POBN?
Chemical properties
white to pale yellow crystalline powder
The Uses of POBN
Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.
The Uses of POBN
POBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide.
What are the applications of Application
POBN is a cell permeable hydrophilic spin trap
Properties of POBN
| Melting point: | 183-185 °C(lit.) |
| Boiling point: | 330.68°C (rough estimate) |
| Density | 1.1444 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | room temp |
| solubility | water: soluble10mg/mL, clear, colorless to faintly yellow |
| form | White to off-white or colorless crystalline solid. |
| pka | 0.76±0.53(Predicted) |
| color | White to Light yellow |
| BRN | 1453764 |
Safety information for POBN
Computed Descriptors for POBN
New Products
4-Fluorophenylacetic acid 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate (6-METHYL-[1,3]DITHIOLO[4,5-b]QUINOXALIN-2-ONE INDAZOLE-3-CARBOXYLIC ACID 4-IODO BENZOIC ACID (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5,6-Dimethoxyindanone 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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