4,4'-DIPYRIDYL DISULFIDE

Synonym(s):4,4′-Dipyridyl disulfide;4,4′-Dithiodipyridine

CAS NO.：2645-22-9
Empirical Formula: C10H8N2S2
Molecular Weight: 220.31
MDL number: MFCD00006423
EINECS: 220-158-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is 4,4'-DIPYRIDYL DISULFIDE?

Chemical properties

white to orange crystalline powder

The Uses of 4,4'-DIPYRIDYL DISULFIDE

Aldrithiol^?-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
It was used to study the O₂ equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
It was used to modify gold surfaces for protein studies.

What are the applications of Application

4,4′-dipyridyl disulfide is used to modify gold surfaces for protein studies

Definition

ChEBI: An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine.

Purification Methods

Recrystallise the disulfide from H2O, EtOH, Me2CO, *C6H6 or pet ether. It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 4-mercaptopyridine (4-pyridinethiol) anion, thereby shifting the max from 324nm (of the disulfide) to 285nm (of the anion) at pH 9. (Compare with 2,2’dipyridyl disulfide above which has been used for the same purpose.) [Humphrey et al. Anal Chem 40 698 1970, Cheng & Ritchie Aust J Chem 26 1785 1973.] [Beilstein 21 II 35, for review see Aldrichimica Acta 4 33 1971.]

Properties of 4,4'-DIPYRIDYL DISULFIDE

Melting point:	76-78 °C(lit.)
Boiling point:	356.1±17.0 °C(Predicted)
Density	1.3078 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	2-8°C
solubility	95% ethanol: soluble5%, clear, colorless to light yellow
form	Crystalline Powder
pka	3.60±0.26(Predicted)
color	White to orange
BRN	154742
CAS DataBase Reference	2645-22-9(CAS DataBase Reference)
NIST Chemistry Reference	Pyridine, 4,4'-dithiobis-(2645-22-9)

Safety information for 4,4'-DIPYRIDYL DISULFIDE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.