PluriSln 1

Synonym(s):Isonicotinic acid 2-phenylhydrazide; 4-Pyridinecarboxylic acid 2-phenylhydrazide;NSC 14613

CAS NO.：91396-88-2
Empirical Formula: C12H11N3O
Molecular Weight: 213.24
MDL number: MFCD02344904
EINECS: 804-702-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is PluriSln 1?

Description

PluriSln-1 (91396-88-2) is an inhibitor of stearoyl-coA desaturase (SCD1). PluriSln-1 was able to selectively eliminate human pluripotent stem cells (hPSCs) while not affecting a large array of progenitor and differentiated cells.1?The ability to eliminate potentially tumorigenic undifferentiated cells is important for increasing the safety of hPSC-based treatments. PluriSln-1 has been used to successfully eliminate tumorigenic cells in cardiomyocytes2?and chondrogenic cells3.

The Uses of PluriSln 1

NSC 14613 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs.

What are the applications of Application

PluriSln 1 is a SCD1 inhibitor and apoptosis inducer

storage

+4°C

References

1) Ben-David?et al. (2013),?Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen; Cell Stem Cell.?12?167 2) Zhang?et al. (2014),?Inhibition of stearoyl-coA desaturase eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium; Cell Cycle?13?762 3) Cheng?et al. (2014),?Cartilage Repair Using Human Embryonic Stem Cell-Derived Chondroprogenitors; Stem Cells Transl. Med.?3?1287

Properties of PluriSln 1

Melting point:	177-178℃
Boiling point:	335.7±15.0 °C(Predicted)
Density	1.251±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: soluble15mg/mL, clear
pka	10.69±0.23(Predicted)
form	powder
color	white to beige
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Safety information for PluriSln 1

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.