Piretanide

Synonym(s):4-Phenoxy-3-(1-pyrrolidinyl)-5-sulfamoylbenzoic acid;Piretanide

CAS NO.：55837-27-9
Empirical Formula: C17H18N2O5S
Molecular Weight: 362.4
MDL number: MFCD00867334
EINECS: 259-852-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is Piretanide?

Chemical properties

Pale Yellow Solid

Originator

Arelix ,Hoechst, Italy ,1980

The Uses of Piretanide

High-ceiling loop diuretic; structurally related to Bumetanide (B689550). Diuretic.

Background

Piretanide (INN, trade names Arelix, Eurelix, Tauliz) has been synthesized in 1973 at Hoechst AG (Germany) as a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups.

Definition

ChEBI: Piretanide is an aromatic ether.

brand name

Arlix (Hoechst-Roussel).

Therapeutic Function

Diuretic

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Used as a diuretic agent. When heated to decomposition it emits very toxic fumes of SOx an

Metabolism

Not Available

Properties of Piretanide

Melting point:	225-227°
Boiling point:	253°C (rough estimate)
Density	1.3049 (rough estimate)
refractive index	1.6510 (estimate)
storage temp.	2-8°C
solubility	Very slightly soluble in water, sparingly soluble in anhydrous ethanol. It shows polymorphism (5.9).
form	neat
pka	10.22±0.60(Predicted)
form	Solid
color	Pale-yellow platelets from MeOH (aq)
CAS DataBase Reference	55837-27-9(CAS DataBase Reference)