Piperidine hydrochloride

CAS NO.：6091-44-7
Empirical Formula: C5H11N.ClH
Molecular Weight: 121.61
MDL number: MFCD00012770
EINECS: 228-033-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-20 14:01:34

What is Piperidine hydrochloride?

Chemical properties

WHITE FINE CRYSTALLINE POWDER

The Uses of Piperidine hydrochloride

Piperidine hydrochloride is used an intermediate in the manufacture of active pharmaceutical ingredients like anti Parkinsonan agent Biperiden; anti depressant agent Clocapramine hydrochloride and muscle relaxant tolperisone.

The Uses of Piperidine hydrochloride

Reagent for synthesis of:

Quinoline selenium compounds
Peripheral seratonin 5-HT3 receptor ligands

Reactant for synthesis of phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors

Reactant for:

Mannich reactions
Asymmetric hydrogenation of quinolines
Chemoselective reductive amination of carbonyl compounds

Purification Methods

Crystallise the salt from EtOH/diethyl ether in the presence of a small amount of HCl. [Beilstein 20 H 6, 20 II 10, 20 III/IV 295, 20/2 V 13.]

Properties of Piperidine hydrochloride

Melting point:	245-248 °C(lit.)
Boiling point:	347.05℃
Density	1,12 g/cm³
vapor density	2.94 (vs air)
vapor pressure	63.6 mm Hg ( 37.8 °C)
Flash point:	>230 °F
storage temp.	Store below +30°C.
solubility	>1500g/l
form	Solid:crystalline
PH	6-8 (111g/l, H2O, 20℃)
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	3611699
CAS DataBase Reference	6091-44-7(CAS DataBase Reference)
EPA Substance Registry System	Piperidine hydrochloride (6091-44-7)

Safety information for Piperidine hydrochloride

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.