Pilocarpine nitrate
Synonym(s):Pilocarpine nitrate salt
- CAS NO.:148-72-1
- Empirical Formula: C11H17N3O5
- Molecular Weight: 271.27
- MDL number: MFCD00078497
- EINECS: 205-723-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Pilocarpine nitrate?
Chemical properties
White or almost white, crystalline powder or colourless crystals, sensitive to light.
The Uses of Pilocarpine nitrate
Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.
The Uses of Pilocarpine nitrate
antiglaucoma agent, miotic
The Uses of Pilocarpine nitrate
Antiglaucoma drug;Cholinergic
What are the applications of Application
Pilocarpine nitrate salt is a nonselectivce muscarinic acetylcholine receptor agonist
brand name
Pilagan (Allergan).
General Description
Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids.
Biochem/physiol Actions
Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.
Properties of Pilocarpine nitrate
Melting point: | 173,5-174°C |
alpha | D +77 to +83° (c = 10) |
refractive index | 81 ° (C=2, H2O) |
storage temp. | 2-8°C |
solubility | H2O: 0.1 g/mL, clear, very faintly yellow |
form | powder |
color | white |
optical activity | [α]25/D +83°, c = 10 in H2O(lit.) |
Merck | 14,7424 |
BRN | 4171406 |
CAS DataBase Reference | 148-72-1(CAS DataBase Reference) |
EPA Substance Registry System | Pilocarpine nitrate (148-72-1) |
Safety information for Pilocarpine nitrate
Signal word | Danger |
Pictogram(s) |
Flame Over Circle Oxidizers GHS03 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H272:Oxidising liquids;Oxidising solids H302:Acute toxicity,oral H330:Acute toxicity,inhalation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P220:Keep/Store away from clothing/…/combustible materials. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for Pilocarpine nitrate
Abamectin manufacturer
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4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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