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HomeProduct name listPilocarpine nitrate

Pilocarpine nitrate

Synonym(s):Pilocarpine nitrate salt

  • CAS NO.:148-72-1
  • Empirical Formula: C11H17N3O5
  • Molecular Weight: 271.27
  • MDL number: MFCD00078497
  • EINECS: 205-723-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Pilocarpine nitrate Structural

What is Pilocarpine nitrate?

Chemical properties

White or almost white, crystalline powder or colourless crystals, sensitive to light.

The Uses of Pilocarpine nitrate

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

The Uses of Pilocarpine nitrate

antiglaucoma agent, miotic

The Uses of Pilocarpine nitrate

Antiglaucoma drug;Cholinergic

What are the applications of Application

Pilocarpine nitrate salt is a nonselectivce muscarinic acetylcholine receptor agonist

brand name

Pilagan (Allergan).

General Description

Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Properties of Pilocarpine nitrate

Melting point: 173,5-174°C
alpha  D +77 to +83° (c = 10)
refractive index  81 ° (C=2, H2O)
storage temp.  2-8°C
solubility  H2O: 0.1 g/mL, clear, very faintly yellow
form  powder
color  white
optical activity [α]25/D +83°, c = 10 in H2O(lit.)
Merck  14,7424
BRN  4171406
CAS DataBase Reference 148-72-1(CAS DataBase Reference)
EPA Substance Registry System Pilocarpine nitrate (148-72-1)

Safety information for Pilocarpine nitrate

Signal word Danger
Pictogram(s)
ghs
Flame Over Circle
Oxidizers
GHS03
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H272:Oxidising liquids;Oxidising solids
H302:Acute toxicity,oral
H330:Acute toxicity,inhalation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P220:Keep/Store away from clothing/…/combustible materials.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for Pilocarpine nitrate

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