PI 828
Synonym(s):2-(4-Morpholinyl)-8-(4-aminophenyl)-4H-1-benzopyrone-4-one, PI-828;LY 294002, 4ʹ-NH₂ - CAS 942289-87-4 - Calbiochem
- CAS NO.:942289-87-4
- Empirical Formula: C19H18N2O3
- Molecular Weight: 322.36
- MDL number: MFCD11100185
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:11
What is PI 828?
What are the applications of Application
LY 294002, 4′-NH2 is a PI 3-kinase inhibitor
Definition
ChEBI: 8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of chromones.
General Description
A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.
Biological Activity
PI 3-Kinase inhibitor (IC 50 values are 0.098, 0.183, 0.227 and 1.967 μ M for p110 β , p110 α , p110 δ and p110 γ respectively) that displays higher potency than LY 294002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride). Can be immobilized onto a solid phase.
storage
Store at +4°C
Properties of PI 828
Boiling point: | 534.2±50.0 °C(Predicted) |
Density | 1.316±0.06 g/cm3(Predicted) |
storage temp. | Store at +4°C |
solubility | DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble |
pka | 4.14±0.10(Predicted) |
form | Off-white solid |
color | White to yellow |
Safety information for PI 828
Computed Descriptors for PI 828
New Products
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