Phosphinothricin
- CAS NO.:51276-47-2
- Empirical Formula: C5H12NO4P
- Molecular Weight: 181.13
- MDL number: MFCD00211362
- EINECS: 257-102-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-08-08 15:53:14
What is Phosphinothricin?
What are the applications of Application
DL-Phosphinotricin is A glutamine synthetase Inhibitor.
Definition
ChEBI: 2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid is a non-proteinogenic alpha-amino acid that is 2-aminobutanoic acid which is substituted at position 4 by a hydroxy(methyl)phosphoryl group. It is a member of phosphinic acids and a non-proteinogenic alpha-amino acid.
Enzyme inhibitor
This dephospho transition-state analogue (FW = 177.10 g/mol; CAS 51276- 47-2) is naturally occurring glutamate analogue, first isolated from Streptomyces viridochromogenes. Phosphonothricin is a slow, tight-binding inhibitor of glutamine synthetase that binds at the glutamate binding site and stabilizes the flap of a glutamyl residue in a position blocking glutamate entry into the active site, thereby trapping the inhibitor on the enzyme. Phosphinothricin undergoes an ATP-dependent phosphorylation. Note: Phosphinothricin is a component of the antibiotics bialaphos and phosalacine. The monoammonium salt of the racemic compound, also called glufosinate-ammonium, is a post-emergent herbicide.
Metabolic pathway
When 14C-phosphinothricin [homoalanin-4-yl- (methyl)phosphinic acid] is incubated in the cell suspension cultures of soybean, wheat, and maize, in maize cells which take up to 50% of the applied radioactivity, four different metabolites are detected which are identified as 4-methylphosphinico-2-oxo- butyric acid, 4-methylphosphinico-2-hydroxybutyric acid, 4-methylphosphinicobutyric acid, and 3- methylphosphinicopropionic acid. In soybean and wheat cultures, 10 and 6% of the applied radioactivity is taken up, respectively. In soybean, only one metabolite, 3-methylphosphinicopropionic acid, is detected, whereas in wheat, 4-methyl- phosphinicobutyric acid is additionally present.
Properties of Phosphinothricin
Melting point: | 229-231° (dec) |
Boiling point: | 519.1±45.0 °C(Predicted) |
Density | 1.378±0.06 g/cm3(Predicted) |
solubility | Aqueous Acid (Slightly), Methanol (Very Slightly, Sonicated), Water (Slightly) |
form | Solid |
pka | 2.22±0.10(Predicted) |
color | White to Light Beige |
Stability: | Hygroscopic |
EPA Substance Registry System | Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)- (51276-47-2) |
Safety information for Phosphinothricin
Computed Descriptors for Phosphinothricin
Abamectin manufacturer
ALS INDIA LIFE SCIENCES
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
You may like
-
51276-47-2 Glufosinate 98%View Details
51276-47-2 -
Glufosinate 98% CAS 51276-47-2View Details
51276-47-2 -
Dechloro DesloratadineView Details
-
Dehydro DesloratadineView Details
-
Edoxaban Impurity 57View Details
2089454-69-1 -
Empagliflozin Bromo ImpurityView Details
-
Glycopyrronium Bromide EP Impurity IView Details
1404617-94-2 -
Ipratropium EP Impurity BView Details
58073-59-9