Phosalone

CAS NO.：2310-17-0
Empirical Formula: C12H15ClNO4PS2
Molecular Weight: 367.81
MDL number: MFCD00055499
EINECS: 218-996-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-01 17:24:36

What is Phosalone?

The Uses of Phosalone

Phosalone is a organophosphate compouund used as insecticide and acaricide. Phosalone is a weak inhibitor of acetylcholinesterase.

The Uses of Phosalone

Insecticide, acaricide.

The Uses of Phosalone

Insecticide; acaracide

The Uses of Phosalone

Phosalone is used to control codling moth, aphids, beetles and thrips on fruit trees

Definition

ChEBI: A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide.

Safety Profile

Poison by ingestion, skin contact,and possibly other routes. A cholinesterase inhibitor. Seealso PARATHION. When heated to decomposition itemits very toxic fumes of Cl^-, NOx, POx, and SOx.

Environmental Fate

Plant. Degrades in plants to chlorbenzoxazolone, formaldehyde and diethyl phosphorodithioate (Hartley and Kidd, 1987)
Soil. Ambrosi et al. (1977a) studied the persistence and metabolism of phosalone in both moist and flooded Matapeake loam and Monmouth fine sandy loam. Phosalone rapidly degraded (half-life 3 to 7 days) but mineralization to carbon dioxide accoun
Chemical/Physical. Emits toxic fumes of chlorine, phosphorus, nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987)

Metabolic pathway

Photodegradation of phosalone in solvent yields dechlorinated phosalone. Irradiation in methanol affords O,O-diethyl-S-methylphosphorothioate and 6- chloro-3-methoxymethyl-2-oxobenzoxazoline with other common products. Photolysis of phosalone in the solid state as a thin film on a glass surface produces a number of photoproducts including 6-chloro-3- mercaptomethyl-2-oxobenzoxazoline and its dimeric disulfide.

Metabolism

Orally administered phosalone in mammals is rapidly degraded by oxidation and hydrolysis to give O,O-diethyl hydrogen phosphorothioate and phosphorodithioate and 6-chloro-2,3-dihydro-2-oxobenzoxazole, which is further metabolized and excreted in the urine. It is strongly adsorbed to soil and rapidly degraded with DT₅₀ values of 1–4 d.

Degradation

Phosalone is hydrolysed by strong acids and alkalis with a DT₅₀, of 9 days at pH 9 (PM).

Properties of Phosalone

Melting point:	47.5-48°
Boiling point:	446.7±55.0 °C(Predicted)
Density	1.39 g/cm3
vapor pressure	<6×10^-5 Pa (25 °C)
Flash point:	100 °C
storage temp.	0-6°C
solubility	DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka	-1.75±0.20(Predicted)
form	solid
Water Solubility	3.05 mg l^-1 (25°C)
color	Crystals
Odor	garlic odor
BRN	694650
Stability:	Hygroscopic
CAS DataBase Reference	2310-17-0(CAS DataBase Reference)
NIST Chemistry Reference	Phosalone(2310-17-0)
EPA Substance Registry System	Phosalone (2310-17-0)

Safety information for Phosalone

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H332:Acute toxicity,inhalation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.