PHORBOL 12,13-DIACETATE
Synonym(s):PDA
- CAS NO.：24928-15-2
- Empirical Formula: C24H32O8
- Molecular Weight: 448.51
- MDL number: MFCD00036735
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is PHORBOL 12,13-DIACETATE?
The Uses of PHORBOL 12,13-DIACETATE
Phorbol 12,13-diacetate may be used to stimulate protein kinase C (PKC) for phosphorylation of retinal proteins.
General Description
Phorbol ester with enhanced hydrophilicity.
Biochem/physiol Actions
Phorbol 12,13-diacetate (PDA) serves as a protein kinase C (PKC). It induces arrest in translocation in rod photoreceptors. PDA facilitates PKC in regulating airway contractility by inducing transient relaxation after a sustained contraction of the human isolated bronchus. PDA improves the synaptic transmission of nociceptive parabrachioamygdaloid (PBA) input onto neurons of the capsular central amygdaloid (CeAC) nucleus via activating PKC and extracellular-regulated kinase (ERK).
Properties of PHORBOL 12,13-DIACETATE
| Boiling point: | 477.23°C (rough estimate) |
| Density | 1.1793 (rough estimate) |
| refractive index | 1.4480 (estimate) |
| storage temp. | −20°C |
| solubility | H2O: soluble |
| form | powder |
| color | white |
| BRN | 2317312 |
Safety information for PHORBOL 12,13-DIACETATE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PHORBOL 12,13-DIACETATE
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