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HomeProduct name listPhenobarbital sodium

Phenobarbital sodium

Synonym(s):5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt;5-Ethyl-5-phenylbarbituric acid sodium salt;Luminal sodium salt;Sodium 5-ethyl-5-phenylbarbiturate

  • CAS NO.:57-30-7
  • Empirical Formula: C12H12N2O3.Na
  • Molecular Weight: 254.22
  • MDL number: MFCD00036211
  • EINECS: 200-322-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:58
Phenobarbital sodium  Structural

What is Phenobarbital sodium ?

Chemical properties

Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y7 (2.2.2, Method II).

The Uses of Phenobarbital sodium

Phenobarbital sodium salt has been used:

  • to anesthetize mice for inducing ischemia-reperfusion injury
  • as a positive control for the activation of constitutive androstane receptor (CAR)
  • in bioluminescent yeast bioreporters (BLYAS) assay

The Uses of Phenobarbital sodium

Anticonvulsant; sedative-hypnotic.

Definition

ChEBI: A barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups).

brand name

Luminal Sodium (Sterling Winthrop).

General Description

Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.

Air & Water Reactions

Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days.

Reactivity Profile

Phenobarbital sodium can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances .

Fire Hazard

Flash point data for Phenobarbital sodium are not available; however, Phenobarbital sodium is probably combustible.

Biochem/physiol Actions

Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA?receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion, intravenous, intraperitoneal, intraduodenal, and subcutaneous routes. Human systemic effects by ingestion: nausea or vomiting and coma. Experimental reproductive effects. Mutation data reported. Used to treat epilepsy, as a hypnotic and sedative. When heated to decomposition it emits toxic fumes of NOx and NazO. See also BARBITURATES

Properties of Phenobarbital sodium

Melting point: 175°C
solubility  H2O: 1 g/mL
form  Solid
color  White to Off-White
PH pH (100g/l, 25℃) : 9.0~11.0
Water Solubility  >=10 g/100 mL at 20 ºC
Merck  13,7319
BRN  3802044
Stability: Hygroscopic
CAS DataBase Reference 57-30-7(CAS DataBase Reference)
EPA Substance Registry System Phenobarbital sodium (57-30-7)

Safety information for Phenobarbital sodium

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H301:Acute toxicity,oral
H317:Sensitisation, Skin
H351:Carcinogenicity
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for Phenobarbital sodium

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