PHALLACIDIN
Synonym(s):Cyclo(Ala-2-Mercapto-Trp-4,5-Dihydroxy-Leu-Val-erythro-3-Hydroxy-D -Asp-Cys-cis-4-Hydroxy-Pro)
- CAS NO.:26645-35-2
- Empirical Formula: C37H50N8O13S
- Molecular Weight: 846.9
- MDL number: MFCD00063359
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:12
What is PHALLACIDIN?
Description
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom, A. phalloides. It binds filamentous actin (F-actin) like phalloidin , but contains a carboxyl group for coupling reactions.
The Uses of PHALLACIDIN
Toxin Phallacidin is a weak fluorescent bicyclic peptide probe in aquous solution, Which is isolated from Amanita phalloides mushroom and could be used for blocking F-actin staining by labeled phallotoxins, which promotes actin polymerization.
The Uses of PHALLACIDIN
Phallacidin is a natural mycotoxin first isolated from the death cap mushroom. It binds filamentous actin like phalloidin.
What are the applications of Application
Phallacidin is an F-actin stabilizing toxin useful for conjugation to fluorescent molecules to actin filaments
Definition
ChEBI: A homodetic bicyclic heptapeptide having a sulfide bridge.
Biochem/physiol Actions
Phallacidin, which is a bicyclic toxin from the Amanita phalloides mushroom, has been shown to inhibit F-actin degradation by proteolytic enzymes including trypsin and α-chymotrypsin.
Enzyme inhibitor
This cyclic heptapeptide toxin (FWfree-acid = 846.92 g/mol; CAS 26645-35-2) from the poisonous green fungus Amanita phalloides stabilizes actin filaments and inhibits actin filament depolymerization. NBD phallacidin is a high-affinity, filamentous actin probe consisting of rabbit actin that is conjugated by reacting its thiol group with 4-chloro-7- nitrobenzofurazan, a yellow-green fluorescent dye. NBD phallacidin (Excitation at 465 nm; Emission at 536 nm) selectively stains F-actin un a manner that is superior to antibody staining, preferably in fixed and permeabilized samples. See Phalloidin
Properties of PHALLACIDIN
Density | 1.1678 (rough estimate) |
refractive index | 1.7400 (estimate) |
solubility | DMF: Soluble; DMSO: Soluble; Methanol: Soluble; Water: Soluble |
form | White to off-white powder. |
color | White to off-white |
Safety information for PHALLACIDIN
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for PHALLACIDIN
New Products
Tubulysin H Tubulysin A Potassium HMDS (1.0 M in THF) 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 4-(Benzyloxy)-3-bromophenylacetic Acid 5-Methyl-1-indanone CYCLOBUTYLAMINE HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride Cyclobutanamine, 3,3-difluoro- (9CI) 3-cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile 3-(7-Nitro-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione 3-Iodo-4-methyl-n-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide ?(S)-2-((S)-2-Cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid 5-Nitro-3-(trifluoromethyl)pyridine-2-carbonitrile Methyl 5-amino-2-(4-nitro-1-oxoisoindolin-2-yl)-5-oxopentanoate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid Methyl (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoate (2R,3S)-2-Azido-3-methylpentanoic acid (R)-methyl 2-isocyano-3-(tritylthio)propanoate (R)-methyl 2-formamido-3-(tritylthio)propanoate HYDROCORTISONE ACETATE EP IMPURITY E FUSIDIC ACID EP IMPURITY O / FUSIDIC ACID BP IMPURITY O / 16-DEACETYL FUSIDIC ACID SODIUM SALTRelated products of tetrahydrofuran
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