PAF (C18)
Synonym(s):1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine
- CAS NO.：74389-69-8
- Empirical Formula: C28H58NO7P
- Molecular Weight: 551.74
- MDL number: MFCD00063528
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is PAF (C18)?
Chemical properties
white solid
The Uses of PAF (C18)
C18-02:0 PC or 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine is suitable as a substrate for enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay.
The Uses of PAF (C18)
C18-02:0 PC or 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine may be used as a substrate in enzymatic lipoprotein-associated phospholipase A2 (Lp-PLA2) activity assay.
What are the applications of Application
PAF C-18 is a naturally occurring phospholipid involved in inflammation and other physiological processes
Definition
ChEBI: 2-acyl-1-alkyl-sn-glycero-3-phosphocholine betaine in which the 1-alkyl and 2-acyl groups are specified as octacdecyl and acetyl respectively
General Description
C18-02:0 PC, also known as 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine (C18∶0-PAF), is a platelet-activating factor lipid. It belongs to a class of natural PAFs and is produced in basophil leucocytes, macrophages, polymorphonuclear neutrophils and monocytes and platelets.
Biochem/physiol Actions
C18-02:0 PC or 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine (C18-PAF), a platelet-activating factor (PAF) facilitates platelet aggregation and secretion. It also plays a key role in inflammation and anaphylaxis. C18-PAF exhibits neurotoxic effects by initiating caspase-independent death in PAF receptor-deficient neurons.
Properties of PAF (C18)
| storage temp. | -20°C |
| solubility | chloroform: 10 mg/mL |
Safety information for PAF (C18)
Computed Descriptors for PAF (C18)
New Products
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![1-OCTADECANOYL-2-[CIS-9-OCTADECENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE](https://img.chemicalbook.in/CAS/GIF/56421-10-4.gif)
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