Paeoniflorin

Synonym(s):NSC 178886;Peoniflorin

CAS NO.：23180-57-6
Empirical Formula: C23H28O11
Molecular Weight: 480.47
MDL number: MFCD00869331
EINECS: 245-476-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-05 11:59:05

What is Paeoniflorin?

Chemical properties

White powder

The Uses of Paeoniflorin

Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin has broad pharmacological effects, such as analgesic, anti-diuretic，anti-inflammatory，anti-convulsant, vasodilatic, and etc. In a study, paeoniflorin effe

The Uses of Paeoniflorin

antiinflammatory, antispasmodic, antihypertensive, antidiuretic

The Uses of Paeoniflorin

Paeoniflorin is an active compound of the Paeonia root. Paeoniflorin inhibits Aβ25-35-induced mitochondrial dysfunction, which includes decreased mitochondrial membrane potential, increased Bax/Bcl-2 ratio, cytochrome c release and activity of caspase-3 and caspase-9. Paeoniflorin could attenuate or restore the viability loss, apoptotic increase, and ROS production induced by Aβ25-35 in SH-SY5Y cells.

What are the applications of Application

Paeoniflorin is a glycoside that activates Adenosine A1-R

Definition

ChEBI: Paeoniflorin is a terpene glycoside.

General Description

Paeoniflorin has been demonstrated to exert anti-inflammatory and immunomodulatory effects.

Biochem/physiol Actions

Herbal constituent of peony root. It is used in Chinese traditional medicine for its spasmolytic and pain-relieving properties. Exhibits anticoagulant, neuromuscular blocking, cognition-enhancing, immunoregulating, and antihyperglycemic effects.

Safety Profile

Moderately toxic by intravenous route. Mildly toxic by intraperitoneal route. When heated to decomposition it emits acrid smoke and irritating fumes.

Properties of Paeoniflorin

Melting point:	approximate 124℃ (dec.)
Boiling point:	498.51°C (rough estimate)
Density	1.3044 (rough estimate)
refractive index	1.5376 (estimate)
storage temp.	2-8°C
solubility	Methanol (Slightly, Sonicated), Pyridine (Slightly)
pka	11.52±0.70(Predicted)
form	powder
color	white
CAS DataBase Reference	23180-57-6(CAS DataBase Reference)

Safety information for Paeoniflorin

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool.