OXONIC ACID POTASSIUM SALT

Synonym(s):Allantoxanic acid;Anti-Kidney superoxide-producing NADPH oxidase;Anti-KOX-1;Anti-NADPH oxidase 4;Anti-Renal NAD(P)H-oxidase

CAS NO.：2207-75-2
Empirical Formula: C4H2KN3O4
Molecular Weight: 195.17
MDL number: MFCD00010565
EINECS: 218-627-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-31 20:01:59

What is OXONIC ACID POTASSIUM SALT?

Description

Oxonic acid is a uricase inhibitor that prevents metabolism and excretion of uric acid and induces embryotoxicity and nephrotoxicity in rats. It is a component of S-1, a mixture containing a prodrug of the antitumor agent 5-fluorouracil (5-FU; ), that suppresses the gastrointestinal toxicity of 5-FU without inhibiting its antitumor activity in rats. Formulations containing oxonic acid have been used to treat gastric, pancreatic, lung, head, neck, and breast carcinomas.

Chemical properties

Off-White Solid

The Uses of OXONIC ACID POTASSIUM SALT

Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats.It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

The Uses of OXONIC ACID POTASSIUM SALT

Antitumor effect potentiator and antitumor agent

The Uses of OXONIC ACID POTASSIUM SALT

Oxonic acid potassium salt is an inhibitor of uricase. The product from Sigma has been used for the inhibition of 5-fluorouracil-induced gastrointestinal toxicity without the loss of its antitumor activity in rats. It has also been used to induce hyperuricemia in rats; as it inhibits uric acid metabolism.

What are the applications of Application

Oxonic Acid Potassium Salt is An antitumor agent and effect potentiator.

Definition

ChEBI: Potassium 2,6-dihydroxytriazinecarboxylate is an organic molecular entity.

Properties of OXONIC ACID POTASSIUM SALT

Melting point:	300 °C(lit.)
storage temp.	Inert atmosphere,2-8°C
solubility	Aqueous Base (Slightly), Water (Slightly, Heated, Sonicated)
form	Powder
color	White
Water Solubility	Soluble in hot water.
CAS DataBase Reference	2207-75-2(CAS DataBase Reference)

Safety information for OXONIC ACID POTASSIUM SALT

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.