Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listOXOMEMAZINE

OXOMEMAZINE

  • CAS NO.:3689-50-7
  • Empirical Formula: C18H22N2O2S
  • Molecular Weight: 330.44
  • MDL number: MFCD00868197
  • EINECS: 222-996-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
OXOMEMAZINE Structural

What is OXOMEMAZINE?

Originator

Doxergan,Specia,France,1964

The Uses of OXOMEMAZINE

(±)-Oxomemazine, is a phenothiazine-type antihistamines, that has also shown antibacterial activity against Mycobacterium tuberculosis.

Definition

ChEBI: Oxomemazine is a member of phenothiazines.

Manufacturing Process

Phenothiazine is reacted with 3-dimethylamino-2-methylpropyl chloride in the presence of sodium amide to give 3-(10-phenthiazinyl)-2-methyl-1dimethylaminopropane. 11.9 g of of this intermediate is dissolved with agitation in glacial acetic acid (120 cc). Pure sulfuric acid (d = 1.83; 0.5 cc) is added and a mixture of glacial acetic acid (10 cc) and hydrogen peroxide (8.5 cc of a solution containing 38 g of hydrogen peroxide in 100 cc) is then run in over 20 minutes. The temperature rises from 25°C to 35°C and is then kept at 60°C for 18 hours. The mixture is cooled and water (150 cc) is added and, with cooling, aqueous sodium hydroxide (d = 1.33; 220 cc). The resulting mixture is extracted with ethyl acetate (3 x 100 cc), the solvent is evaporated on a water bath and the residue is recrystallized from heptane (150 cc). 3(9,9-dioxy-10-phenthiazinyl)-2-methyl-1-dimethylaminopropane (78 g) is obtained, MP 115°C.
The corresponding hydrochloride prepared in ethyl acetate and recrystallized from a mixture of ethanol and isopropanol melts at 250°C.

Therapeutic Function

Antihistaminic

Properties of OXOMEMAZINE

Melting point: 115°
Boiling point: 492.4±34.0 °C(Predicted)
Density  1.1453 (rough estimate)
refractive index  1.6000 (estimate)
storage temp.  Store at -20°C
solubility  ≥ 33mg/mL in DMSO
form  Solid
pka 9.31±0.28(Predicted)
color  White to off-white

Safety information for OXOMEMAZINE

Computed Descriptors for OXOMEMAZINE

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.