OXAMFLATIN
- CAS NO.:151720-43-3
- Empirical Formula: C17H14N2O4S
- Molecular Weight: 342.37
- MDL number: MFCD00949087
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is OXAMFLATIN?
Chemical properties
Red-Brown Solid
The Uses of OXAMFLATIN
Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.
What are the applications of Application
Oxamflatin is a potent inhibitor of HDACs (histone deacetylases)
Definition
ChEBI: 5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide is a sulfonamide.
Enzyme inhibitor
This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).
Properties of OXAMFLATIN
Melting point: | 98-100°C |
Density | 1.44±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: 13 mg/mL, soluble |
form | solid |
pka | 7.75±0.10(Predicted) |
color | Light yellow to yellow |
Stability: | Light sensitive |
Safety information for OXAMFLATIN
Computed Descriptors for OXAMFLATIN
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