HC TOXIN

CAS NO.：83209-65-8
Empirical Formula: C21H32N4O6
Molecular Weight: 436.51
MDL number: MFCD29924706
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:03

What is HC TOXIN?

Description

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC₅₀ = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

The Uses of HC TOXIN

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

What are the applications of Application

HC Toxin is an HDAC inhibitor

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Biochem/physiol Actions

Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.

Properties of HC TOXIN

Boiling point:	819.2±65.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 10 mg/ml; Methanol: 10 mg/ml
form	lyophilized powder
pka	13.33±0.70(Predicted)
color	Off-white to light yellow

Safety information for HC TOXIN

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H300:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.