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HomeProduct name listHC TOXIN

HC TOXIN

HC TOXIN Structural

What is HC TOXIN?

Description

HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells. HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.

The Uses of HC TOXIN

HC Toxin is an HDAC inhibitor. Cyclic tetrapeptide[1] fungal toxin selectively toxic to plants with susceptible host genotype (2)

What are the applications of Application

HC Toxin is an HDAC inhibitor

Definition

ChEBI: A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues.

Biochem/physiol Actions

Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.

Properties of HC TOXIN

Boiling point: 819.2±65.0 °C(Predicted)
Density  1.28±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 10 mg/ml; Methanol: 10 mg/ml
form  lyophilized powder
pka 13.33±0.70(Predicted)
color  Off-white to light yellow

Safety information for HC TOXIN

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H300:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for HC TOXIN

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