Oseltamivir phosphate
Synonym(s):(3R,4R,5S)-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester phosphate salt;GS4104;Oseltamivir phosphate
- CAS NO.:204255-11-8
- Empirical Formula: C16H31N2O8P
- Molecular Weight: 410.4
- MDL number: MFCD08059548
- EINECS: 616-396-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-16 10:38:43
What is Oseltamivir phosphate?
Description
Oseltamivir phosphate (Tamiflu) was launched in the US and Switzerland for the treatment of influenza infections by all common strain viruses. It is an oral anti-viral drug approved for the treatment of acute, uncomplicated influenza in patients 2 weeks of age and older whose flu symptoms have not lasted more than two days. This product is approved to treat Type A and B influenza; however, the majority of patients included in the studies were infected with type A, the most common in the U.S. Efficacy of Tamiflu in the treatment of influenza in subjects with chronic cardiac disease and/or respiratory disease has not been established.
Description
The 2017–2018 flu season is seeing record numbers of cases, hospitalizations, and pediatric deaths. ?Oseltamivir phosphate (usually shortened to oseltamivir), a prescription drug used to prevent and treat influenza, is in high demand. Best known by its trade name Tamiflu, it can be effective against influenza A and influenza B, which are genera of the Orthomyxoviridae virus family.
Oseltamivir, even when it does work, reduces the duration of flu symptoms by only 12–24 h. Some people take it prophylactically, but the US Centers for Disease Control and Prevention does not recommend this practice because it may cause the viruses to develop resistance to the drug. The exception is that high-risk individuals should take it if they have not been (or have only recently been) vaccinated and have been exposed to flu in the previous 48 h.
The irony is that many, if not most, high-risk people are more than 65 years old. But oseltamivir does not work as well in seniors as it does with younger people.
The Uses of Oseltamivir phosphate
Oseltamivir phosphate (Tamiflu) is a competitive neuraminidase inhibitor. The prodrug oseltamivir phosphate (Tamiflu) is itself not virally effective; however, once in the liver, it is converted by natural chemical processes, hydrolysed hepatically to its
What are the applications of Application
Oseltamivir phosphate is an antiviral agent
Properties of Oseltamivir phosphate
Melting point: | 196-198°C |
storage temp. | 2-8°C |
solubility | H2O: soluble30mg/mL, clear |
form | powder |
appearance | white crystals |
color | white to beige |
Safety information for Oseltamivir phosphate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Oseltamivir phosphate
InChIKey | PGZUMBJQJWIWGJ-IFAKAUOZSA-N |
SMILES | [C@@H]1(OC(CC)CC)C=C(C[C@H](N)[C@H]1NC(=O)C)C(=O)OCC.OP(O)(O)=O |&1:0,10,12,r| |
Abamectin manufacturer
SGMR PHARMACEUTICALS PVT LTD
Lupin Ltd
Everest Organics Limited
Solara Active Pharma Sciences Ltd
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