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HomeProduct name listORPHENADRINE HYDROCHLORIDE

ORPHENADRINE HYDROCHLORIDE

Synonym(s):β-Dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride;N,N-Dimethyl-2-(2-methylbenzhydryloxy)ethylamine hydrochloride;o-Methyldiphenhydramine hydrochloride

  • CAS NO.:341-69-5
  • Empirical Formula: C18H24ClNO
  • Molecular Weight: 305.84
  • MDL number: MFCD00012480
  • EINECS: 206-435-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
ORPHENADRINE HYDROCHLORIDE Structural

What is ORPHENADRINE HYDROCHLORIDE?

Chemical properties

White or almost white, crystalline powder.

The Uses of ORPHENADRINE HYDROCHLORIDE

Antihistaminic;H1 antogonist

Definition

ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.

General Description

Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.

Air & Water Reactions

May be sensitive to prolonged exposure to light and air. Water soluble.

Reactivity Profile

ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.

Fire Hazard

Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.

Biochem/physiol Actions

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Clinical Use

Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl

Metabolism

Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug

Properties of ORPHENADRINE HYDROCHLORIDE

Melting point: 159.0 to 164.0 °C
Boiling point: -195 °C
Density  0.295 g/cm3
storage temp.  2-8°C
solubility  Freely soluble in water and in ethanol (96 per cent).
form  neat
color  Crystals
BRN  3745818
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 341-69-5(CAS DataBase Reference)
EPA Substance Registry System Orphenadrine hydrochloride (341-69-5)

Safety information for ORPHENADRINE HYDROCHLORIDE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for ORPHENADRINE HYDROCHLORIDE

Abamectin manufacturer

R L Fine Chem Pvt. Ltd

1Y
Phone:+91-8042488999
product: 341-69-5 Orphenadrine hydrochloride 98%
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Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 341-69-5 98%
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Kores India Limited (Kores Pharmaceuticals And Chemicals)

1Y
Phone:+91-2227613455
product: Orphenadrine hydrochloride 98%
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