OPHIOPOGONIN D

CAS NO.：945619-74-9
Empirical Formula: C44H70O16
Molecular Weight: 855.03
MDL number: MFCD09970543
Update Date: 2024-11-19 23:02:33

What is OPHIOPOGONIN D?

The Uses of OPHIOPOGONIN D

Ophiopogonin D is a natural product isolated from Radix Ophiopogon japonicus that protects the heart against doxorubicin-induced autophagic injury by reduction of both ROS generation and the disruption of the mitochondrial membrane damage.

What are the applications of Application

Ophiopogonin D is a bioactive compound that is found in Salvia miltiorrhiza. It has been shown to have hypoglycemic effects and significant cytotoxicity against tumor cells, which may be due to its ability to inhibit glucose uptake. It also causes mitochondrial membrane potential reduction, leading to the induction of apoptosis. This compound also has immunomodulatory effects. In addition, it inhibits the activation of toll-like receptors and prevents the translocation of nuclear factor-κB into the nucleus. Ophiopogonin D also has an effect on bowel disease, myocardial infarcts, and energy metabolism by inhibiting c-jun phosphorylation.

Definition

ChEBI: Ophiopogonin D is a steroid saponin.

Properties of OPHIOPOGONIN D

Melting point:	263-265 °C
Density	1.40
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMF:30.0(Max Conc. mg/mL);35.09(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);35.09(Max Conc. mM) Ethanol:15.0(Max Conc. mg/mL);17.54(Max Conc. mM)
form	A solid
pka	13.01±0.70(Predicted)
color	White to off-white