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HomeProduct name listOmethoate

Omethoate

  • CAS NO.:1113-02-6
  • Empirical Formula: C5H12NO4PS
  • Molecular Weight: 213.19
  • MDL number: MFCD00055441
  • EINECS: 214-197-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:33
Omethoate Structural

What is Omethoate?

The Uses of Omethoate

Omethoate is a systemic insecticide used for the control of (mostly) sucking insects and mites in a wide variety of crops.

The Uses of Omethoate

Insecticidal, acaricidal, and fungicidal combinations of carboxamides and other pesticides.

What are the applications of Application

Omethoate is an insecticidal, acaricidal, and fungicidal combination of carboxamides and other pesticides

Definition

ChEBI: Omethoate is an organic thiophosphate and an organothiophosphate insecticide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a N-methyl-2-sulfanylacetamide.

Contact allergens

Contact dermatitis from omethoate-dimethoxon is rare.

Metabolic pathway

Omethoate is the P=O analogue (oxon) of dimethoate. Dimethoate is metabolised via oxidative desulfuration to omethoate which is the active anti-acetylcholinesterase metabolite. This biotransformation occurs in all media: hence the metabolic pathways of both compounds have much in common. However, degradative pathways acting directly on dimethoate such as O-demethylation, N-demethylation and hydrolysis of the amide function mean that the balance between activation and degradative metabolism will influence their respective selective toxicities. In mammals there are two main routes of degradation: (i) glutathione transferase mediated O-demethylation (ii) hydrolysis to N-methylthioglycolamide which is S-methylated by S-adenosylmethionine and subsequently thiooxidised. In soil and plants the N-methylthioglycolamide moiety formed from the hydrolysis of omethoate undergoes a complex series of C1, C2 and C3 biotransformations ultimately leading to oxalate and citrate respectively and total degradation to C02. The information reported below is derived largely from an evaluation prepared by the UK MAFF Pesticide Safety Directorate (PSD, 1993).

Metabolism

Orally administered omethoate to rats is rapidly metabolized and excreted in the urine; the main metabolites are O-demethylomethoate and N-methyl-2- methylsulfinylacetamide. O-Demethylation and hydrolysis of the P?S bond are main degradation routes both in mammals and plants. Omethoate is rapidly degraded in soils with DT50 of a few days.

Degradation

Omethoate was slowly hydrolysed in acidic media but more rapidly under alkaline conditions. The half-lives for hydrolysis at pH 4,7, and 9 were 102 days, 17 days and 28 hours, respectively (PM). Omethoate does not absorb light at wavelengths above 250 nm and it is thus unlikely to be subject to photodecomposition. An aqueous solution of omethoate was irradiated for 14 hours with a high pressure filtered mercury vapour lamp without detectable photolysis occurring (PSD, 1993).

Toxicity evaluation

The acute oral LD50 for rats is about 25 mg/kg. Inhalation LC50 (4 h) for rats is 0.3 mg/L air. ADI is 0.3 μg/kg b.w.

Properties of Omethoate

Melting point: -27.9°C
Boiling point: 135°C
Density  1.3200
vapor pressure  3.3×10-3Pa (20 °C)
Flash point: 100 °C
storage temp.  0-6°C
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka 14.40±0.46(Predicted)
form  liquid
Water Solubility  Miscible
BRN  1785256
Stability: Hygroscopic
CAS DataBase Reference 1113-02-6(CAS DataBase Reference)
NIST Chemistry Reference Omethoate(1113-02-6)
EPA Substance Registry System Omethoate (1113-02-6)

Safety information for Omethoate

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H300:Acute toxicity,oral
H311:Acute toxicity,dermal
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Omethoate

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