OLIGOMYCIN C
- CAS NO.:11052-72-5
- Empirical Formula: C45H74O10
- Molecular Weight: 775.06
- MDL number: MFCD32182610
- EINECS: 234-276-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:36
What is OLIGOMYCIN C?
Description
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase. Inhibition of the ATP synthase by oligomycins leads to cell death.
The Uses of OLIGOMYCIN C
Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.
The Uses of OLIGOMYCIN C
Oligomycin C is an ATP synthetase and RVD inhibitor.
What are the applications of Application
Oligomycin C is an ATP synthetase and RVD inhibitor
Safety Profile
A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors
References
[1]. yang p w, li m g, zhao j y, et al. oligomycins a and c, major secondary metabolites isolated from the newly isolated strain streptomyces diastaticus[j]. folia microbiologica, 2010, 55(1): 10-16.
[2]. marton a, mihalik r, bratincsák a, et al. apoptotic cell death induced by inhibitors of energy conservation[j]. european journal of biochemistry, 1997, 250(2): 467-475.
Properties of OLIGOMYCIN C
Boiling point: | 876.2±65.0 °C(Predicted) |
Density | 1.091 g/cm3 |
storage temp. | −20°C |
solubility | Soluble in DMSO |
form | White to off-white powder. |
pka | 13.49±0.70(Predicted) |
Merck | 13,6902 |
Safety information for OLIGOMYCIN C
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. |
Computed Descriptors for OLIGOMYCIN C
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