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HomeProduct name listOLEYLOXYETHYL PHOSPHORYLCHOLINE

OLEYLOXYETHYL PHOSPHORYLCHOLINE

OLEYLOXYETHYL PHOSPHORYLCHOLINE Structural

What is OLEYLOXYETHYL PHOSPHORYLCHOLINE?

Description

Oleyloxyethyl phosphorylcholine is an inhibitor of PLA2 with an IC50 value of 6.2 μM for porcine pancreatic PLA2.

What are the applications of Application

Oleyloxyethyl Phosphorylcholine is an inhibitor of PLA2

in vitro

to examine the phospholipids including oleyloxyethyl phosphorylcholine as pla2 inhibitors, the enzyme assay was employed. determinations were performed below critical micelle concentration. porcine pancreatic pla2 and phospholipid inhibitor were preincubated for 2 min at 37°c in buffer at ph 8.5. introduction of [l4c]arachidonate phosphatidylcholine initiated the enzymatic reaction, which is quenched after 5 min at 37°c. in this manner 50% inhibitor concentrations were determined for mepacrine and alkylphosphorylcholines, indicating oleyloxyethyl phosphorylcholine was an inhibitor of pla2 with an ic50 of 6.2 μm for porcine pancreatic pla2 [1].

References

[1] magolda, r. l.,ripka, w.c.,galbraith, w., et al. novel synthesis of potent site-specific phospholipase a2 inhibitors. book: prostaglandins, leukotrienes and lipoxins 669-676 (1985).

Properties of OLEYLOXYETHYL PHOSPHORYLCHOLINE

storage temp.  -20°C
solubility  ≤16mg/ml in DMSO;16mg/ml in dimethyl formamide
form  solution in ethanol.
color  Colorless to light yellow

Safety information for OLEYLOXYETHYL PHOSPHORYLCHOLINE

Computed Descriptors for OLEYLOXYETHYL PHOSPHORYLCHOLINE

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