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HomeProduct name listOleyl alcohol

Oleyl alcohol

Synonym(s):cis-9-Octadecen-1-ol;Z-9-Dodecen-1-ol;cis-9-Octadecen-1-ol;Oleyl alcohol

  • CAS NO.:143-28-2
  • Empirical Formula: C18H36O
  • Molecular Weight: 268.48
  • MDL number: MFCD00002993
  • EINECS: 205-597-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-24 21:11:45
Oleyl alcohol Structural

What is Oleyl alcohol?

Chemical properties

Colourless or light yellow liquid.

Chemical properties

Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid fumes when heated.

Chemical properties

Colorless to light yellow liquid; fatty aroma with animal undertones.

The Uses of Oleyl alcohol

oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential.

The Uses of Oleyl alcohol

Chiefly in the manufacture of its sulfuric esters which are detergents and wetting agents, as an antifoam agent; metal cutting lubricant; in carbon paper, stencil paper, printing ink; as a plasticizer; for softening and lubricating textile fabrics; carrier for medicaments.

The Uses of Oleyl alcohol

Oleyl alcohol is used in softening and lubrication of textile fabrics, and in the production of carbon paper, stencil paper, and printing ink. It finds application in cosmetic products viz skin creams and lotions as a thickner, hair conditioners and hair coating shampoos. It is utilized as an antifoaming agent and cutting lubricant, as the precursor for the preparation of its sulfuric ester derivatives, which are used in detergents and wetting agents. It plays a vital role in various formulations for drug delivery.

What are the applications of Application

Oleyl alcohol is a long-chain, unsaturated fatty alcohol that can be used as an emulsifier, nonionic surfactant and thickener

Definition

ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).

Production Methods

Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be prepared from butyl oleate by a Bouveault–Blanc reduction with sodium and butyl alcohol. An alternative method of manufacture is by the hydrogenation of triolein in the presence of zinc chromite.

brand name

Witcohol 85 (Witco); Witcohol 90 (Witco).

Aroma threshold values

Fatty-type, medium strength odor.

General Description

Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Oleyl alcohol is mainly used in topical pharmaceutical formulations and has been used in transdermal delivery formulations.It has been utilized in the development of biodegradable injectable thermoplastic oligomers,and in aerosol formulations of insulin and albuterol.
Therapeutically, it has been suggested that oleyl alcohol may exhibit antitumor properties via transmembrane permeation.

Safety Profile

A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes.

Safety

Oleyl alcohol is mainly used in topical pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, contact dermatitis due to oleyl alcohol has been reported.
The results of acute oral toxicity and percutaneous studies in animals with products containing 8% oleyl alcohol indicate a very low toxicity. Formulations containing 8% or 20% oleyl alcohol administered by gastric intubation, at doses up to 10 g/kg bodyweight, caused no deaths and no toxic effects in rats.

storage

The bulk material should be stored in a well-closed container in a cool, dry, place.

Purification Methods

Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.]

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical emulsions and ointments). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Properties of Oleyl alcohol

Melting point: 0-5.0 °C (lit.)
Boiling point: 207 °C/13 mmHg (lit.)
Density  0.849 g/mL at 25 °C (lit.)
vapor pressure  10.64 hPa (195 °C)
FEMA  4363 | CIS-9-OCTADECENOL
refractive index  n20/D 1.46(lit.)
Flash point: >230 °F
storage temp.  -20°C
solubility  Soluble in ethanol (95%), and ether; practically insoluble in water.
form  Viscous Liquid
pka 15.20±0.10(Predicted)
color  Clear almost colorless to yellow
Odor fatty animal
Water Solubility  Miscible with alcohol and ether. Slightly miscible with carbon tetrachloride. Immiscible with water.
JECFA Number 1637
Merck  14,6831
BRN  1723962
Stability: Stable. Combustible. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference 143-28-2(CAS DataBase Reference)
NIST Chemistry Reference Oleyl Alcohol(143-28-2)
EPA Substance Registry System 9-Octadecen-1-ol, (9Z)- (143-28-2)

Safety information for Oleyl alcohol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H320:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P321:Specific treatment (see … on this label).
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

Computed Descriptors for Oleyl alcohol

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