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HomeProduct name listO-PHOSPHORYLETHANOLAMINE

O-PHOSPHORYLETHANOLAMINE

Synonym(s):O-Phosphocolamine;O-Phosphoethanolamine;2-Aminoethyl dihydrogen phosphate;Colamine phosphoric acid, Ethanolamine dihydrogen phosphate, 2-Hydroxyethylammonium dihydrogen phosphate, O-Phosphoethanolamine;Colaminephosphoric acid

  • CAS NO.:1071-23-4
  • Empirical Formula: C2H8NO4P
  • Molecular Weight: 141.06
  • MDL number: MFCD00008178
  • EINECS: 213-988-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-01 18:09:03
O-PHOSPHORYLETHANOLAMINE Structural

What is O-PHOSPHORYLETHANOLAMINE?

Chemical properties

O-PHOSPHORYLETHANOLAMINE is white powder

The Uses of O-PHOSPHORYLETHANOLAMINE

O-PHOSPHORYLETHANOLAMINEe is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane.

The Uses of O-PHOSPHORYLETHANOLAMINE

O-Phosphorylethanolamine has been used:

  • in LHC-8 medium as a supplement in culturing the transformed human liver epithelial (THLE)-2 and THLE-3 cells
  • in C-reactive protein (CRP) binding sucrose flotation experiment
  • to incubate phosphomonoesters with anion-exchange chromatography (AEC) fractions for the detection of phosphatase activity
  • to add in the washed beads for the preparation of phosphorylethanolamine (Pet) -conjugated sepharose column for chromatographic purification of mutant CRP

Definition

ChEBI: The ethanolamine mono-ester of phosphoric acid, and a metabolite of phospholipid metabolism. This phosphomonoester shows strong structural similarity to the inhibitory neurotransmitter GABA, and is decreased in post-mortem Alzheimer's disease brain.

Biochem/physiol Actions

Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer′s and Huntington′s disease.

Purification Methods

Purification by recrystallisation from aqueous EtOH gives a hydrate (m 140-141o). Its solubility in H2O is 17% and 0.003% in MeOH or EtOH at 22o. [F.lisch & .sterberg J Biol Chem 234 2298 1959, Baer & Staucer Can J Chem 34 434 1956, Christensen J Biol Chem 135 399 1940.] It is a potent inhibitor of ornithine decarboxylase [Gilad & Gilad Biochem Biophys Res Commun 122 277 1984]. [Beilstein 4 IV 1415.]

Properties of O-PHOSPHORYLETHANOLAMINE

Melting point: 241-243 °C(lit.)
Boiling point: 335.8±44.0 °C(Predicted)
Density  1.554±0.06 g/cm3(Predicted)
storage temp.  Store below +30°C.
solubility  PBS (pH 7.2): 10 mg/ml
Water Solubility  Soluble in water
form  powder to crystal
pka pK1:5.838(+1);pK2:10.638(0) (25°C)
color  White to Light yellow
BRN  1758916
CAS DataBase Reference 1071-23-4(CAS DataBase Reference)
EPA Substance Registry System Ethanol, 2-amino-, dihydrogen phosphate (ester) (1071-23-4)

Safety information for O-PHOSPHORYLETHANOLAMINE

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H314:Skin corrosion/irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P310:Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for O-PHOSPHORYLETHANOLAMINE

InChIKey SUHOOTKUPISOBE-UHFFFAOYSA-N

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