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HomeProduct name listO-DESMETHYLGALANTHAMINE

O-DESMETHYLGALANTHAMINE

O-DESMETHYLGALANTHAMINE Structural

What is O-DESMETHYLGALANTHAMINE?

Chemical properties

Pale Yellow Powder

The Uses of O-DESMETHYLGALANTHAMINE

A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor

The Uses of O-DESMETHYLGALANTHAMINE

A metabolite of Galanthamine (G188500), a selective acetylcholinesterase inhibitor.

The Uses of O-DESMETHYLGALANTHAMINE

Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.

What are the applications of Application

O-Desmethyl galanthamine is a major galanthamine metabolite

Definition

ChEBI: Sanguinine is a benzazepine.

Properties of O-DESMETHYLGALANTHAMINE

Melting point: 227-230°C (dec.)
Boiling point: 451.9±45.0 °C(Predicted)
Density  1.37±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  DMSO: soluble
form  A solid
pka 9.39±0.40(Predicted)
color  White to off-white
CAS DataBase Reference 60755-80-8

Safety information for O-DESMETHYLGALANTHAMINE

Computed Descriptors for O-DESMETHYLGALANTHAMINE

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