O-DESMETHYLGALANTHAMINE
- CAS NO.：60755-80-8
- Empirical Formula: C16H19NO3
- Molecular Weight: 273.33
- MDL number: MFCD07369289
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 20:21:46
What is O-DESMETHYLGALANTHAMINE?
Chemical properties
Pale Yellow Powder
The Uses of O-DESMETHYLGALANTHAMINE
A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor
The Uses of O-DESMETHYLGALANTHAMINE
A metabolite of Galanthamine (G188500), a selective acetylcholinesterase inhibitor.
The Uses of O-DESMETHYLGALANTHAMINE
Sanguinine has a more potent acetylcholinesterase inhibitory activity than galanthamine due to an extra hydroxyl group available for potential interaction with acetylcholinesterase. Sanguinine, in turn, is 10-fold more selective than galanthamine for acetylcholinesterase (AChE) vs. butyrylcholinesterase (BuChE). The lack of AChE inhibitory activity of lycoramine and epinorlicoramine could be due to the occurrence of a double bond in ring C, which does not allow these alkaloids to have the same spatial configuration as the active alkaloids of this series.
What are the applications of Application
O-Desmethyl galanthamine is a major galanthamine metabolite
Definition
ChEBI: Sanguinine is a benzazepine.
Properties of O-DESMETHYLGALANTHAMINE
| Melting point: | 227-230°C (dec.) |
| Boiling point: | 451.9±45.0 °C(Predicted) |
| Density | 1.37±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | DMSO: soluble |
| form | A solid |
| pka | 9.39±0.40(Predicted) |
| color | White to off-white |
| CAS DataBase Reference | 60755-80-8 |
Safety information for O-DESMETHYLGALANTHAMINE
Computed Descriptors for O-DESMETHYLGALANTHAMINE
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