CALPHOSTIN C
Synonym(s):Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem;UCN-1028c
- CAS NO.:121263-19-2
- Empirical Formula: C44H38O14
- Molecular Weight: 790.76
- MDL number: MFCD00133155
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is CALPHOSTIN C?
Chemical properties
Dark red solid
The Uses of CALPHOSTIN C
Calphostin C (CGP049090) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumour cell lines.
The Uses of CALPHOSTIN C
Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.
The Uses of CALPHOSTIN C
Potent inhibitor of protein kinase C
What are the applications of Application
Calphostin C is an inhibitor of PKC, PKA, PKG, and calcium channel proteins
Biological Activity
Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC 50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC 50 ~ 40-60 nM).
Biochem/physiol Actions
Highly specific inhibitor of protein kinase C (IC50 = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.
storage
+4°C (desiccate)
Properties of CALPHOSTIN C
Boiling point: | 1039.8±65.0 °C(Predicted) |
Density | 1.48±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMF: 1 mg/mL |
form | powder |
pka | 7.30±0.20(Predicted) |
color | red to brown |
Safety information for CALPHOSTIN C
Computed Descriptors for CALPHOSTIN C
New Products
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