NS 3694
Synonym(s):Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem;NS3694
- CAS NO.:426834-38-0
- Empirical Formula: C15H10ClF3N2O3
- Molecular Weight: 358.7
- MDL number: MFCD00249000
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:09
What is NS 3694?
Description
Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.
The Uses of NS 3694
NS3694 is a suppressor of the formation of apoptosome Apaf-1.
What are the applications of Application
NS3694 is a suppressor of the formation of apoptosome Apaf-1
Definition
ChEBI: 4-chloro-2-[[oxo-[3-(trifluoromethyl)anilino]methyl]amino]benzoic acid is a member of ureas.
in vitro
previous study found that ns3694, and its two analogs (ns1764 and ns1784) were well-tolerated by mcf-7s1 breast cancer cells at concentrations up to 100, 50, and 25 μm, respectively. moreove, all three compounds could not inhibit recombinant caspase 9 and caspase 3 at concentrations ranging from 25 to 100 μm. in addition, ns3694 was able to inhibit the co-immunoprecipitation of caspase 9 and apaf-1 from hela cell cytosol stimulated by cytochrome c and datp. ns3694 could also inhibit the formation of the active 700-kda apoptosome complex, but had no effect on tnf-induced caspase-independent death of wehi-s cells. ns3694 did not inhibit fasl-induced caspase activation or death in type i cells neither [1].
References
[1] lademann, u. ,cain, k.,gyrd-hansen, m., et al. diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. mol.cell biol. 23(21), 7829-7837 (2003).
Properties of NS 3694
storage temp. | 2-8°C |
solubility | DMSO: 22 mg/mL, soluble |
form | solid |
color | Off-white to light yellow |
Safety information for NS 3694
Computed Descriptors for NS 3694
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Rimegepant Impurity 3 Ivermectin EP Impurity B Fosfomycin EP impurity D Tubulysin A (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate 2,2-diethoxyethanethioamide Tubulysin C Tubulysin I Tubulysin D 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 4,8-dibromo-5H-[1,2,3]triazolo[4',5':4,5]benzo[1,2-c][1,2,5]thiadiazole 1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 1-(4-Chlorophenyl)piperidin-2-one 3,6-Bis(4-bromophenyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione (1-Isopropyl-1H-pyrazol-5-yl)boronic acid 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (4R,12aR)-7-Methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1`,2`;4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acidRelated products of tetrahydrofuran
You may like
-
NS3694 CAS 426834-38-0View Details
426834-38-0 -
Apoptosis Inhibitor II, NS3694 CAS 426834-38-0View Details
426834-38-0 -
3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dioneView Details
952145-70-9 -
Sidchem 730View Details
-
Sidchem BT 20View Details
-
1572177-89-9View Details
1572177-89-9 -
6390-09-6View Details
6390-09-6 -
6-Bromo indoleView Details