NS-2028

Synonym(s):4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one;4H-8-Bromo-1,2,4-oxadiazolo[3,4-d]benz[b][1,4]oxazin-1-one;NS 2028 - CAS 204326-43-2 - Calbiochem

CAS NO.：204326-43-2
Empirical Formula: C9H5BrN2O3
Molecular Weight: 269.05
MDL number: MFCD01530052
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is NS-2028?

The Uses of NS-2028

NS-2028 potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). NS-2028 blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA. NS-2028 inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC).

The Uses of NS-2028

NS-2028 is a specific inhibitor of soluble guanylyl cyclase. It inhibits purified bovine lung guanylyl cyclase in a concentration dependent and irreversible manner with IC50 values of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. S-nitroso-glutathione-enhanced guanylyl cyclase activity in mouse cerebellum homogenates is inhibited by NS-2028 with an IC50 value of 17 nM, making it about 4.7 fold more potent than ODQ, which has an IC50 value of 80 nM for inhibition of soluble guanylyl cyclase in the same assay. NS-2028 does not inhibit particulate guanylyl cyclase or adenylyl cyclase.

What are the applications of Application

NS 2028 is a potent, specific, and irreversible inhibitor of soluble guanylyl cyclase

storage

Store at +4°C

Properties of NS-2028

Melting point:	160～170℃
Boiling point:	353.8±52.0 °C(Predicted)
Density	2.06±0.1 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	DMSO: 13 mg/mL
form	solid
pka	-1.18±0.20(Predicted)
color	white