6-ANILINO-5,8-QUINOLINEDIONE

Synonym(s):6-(Phenylamino)-5,8-quinolinedione;6-Anilino-5,8-quinolinequinone;LY 83583 - CAS 91300-60-6 - Calbiochem;LY-83,583;LY83583

CAS NO.：91300-60-6
Empirical Formula: C15H10N2O2
Molecular Weight: 250.25
MDL number: MFCD00210756
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-30 21:47:27

What is 6-ANILINO-5,8-QUINOLINEDIONE?

Chemical properties

Red-Brown Solid

The Uses of 6-ANILINO-5,8-QUINOLINEDIONE

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release

The Uses of 6-ANILINO-5,8-QUINOLINEDIONE

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.

The Uses of 6-ANILINO-5,8-QUINOLINEDIONE

LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 μM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 μM.[Cayman Chemical]

What are the applications of Application

LY 83583 is an inhibitor of guanylate cyclase

Definition

ChEBI: A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.

Properties of 6-ANILINO-5,8-QUINOLINEDIONE

Melting point:	184-185°C
Boiling point:	446.9±45.0 °C(Predicted)
Density	1.400±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	0.1 M HCl: 1 mg/mL
form	solid
pka	-0.63±0.20(Predicted)
color	violet
CAS DataBase Reference	91300-60-6(CAS DataBase Reference)

Safety information for 6-ANILINO-5,8-QUINOLINEDIONE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection.