6-ANILINO-5,8-QUINOLINEDIONE
Synonym(s):6-(Phenylamino)-5,8-quinolinedione;6-Anilino-5,8-quinolinequinone;LY 83583 - CAS 91300-60-6 - Calbiochem;LY-83,583;LY83583
- CAS NO.：91300-60-6
- Empirical Formula: C15H10N2O2
- Molecular Weight: 250.25
- MDL number: MFCD00210756
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-30 21:47:27
What is 6-ANILINO-5,8-QUINOLINEDIONE?
Chemical properties
Red-Brown Solid
The Uses of 6-ANILINO-5,8-QUINOLINEDIONE
Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release
The Uses of 6-ANILINO-5,8-QUINOLINEDIONE
Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.
The Uses of 6-ANILINO-5,8-QUINOLINEDIONE
LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 μM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 μM.[Cayman Chemical]
What are the applications of Application
LY 83583 is an inhibitor of guanylate cyclase
Definition
ChEBI: A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.
Properties of 6-ANILINO-5,8-QUINOLINEDIONE
| Melting point: | 184-185°C |
| Boiling point: | 446.9±45.0 °C(Predicted) |
| Density | 1.400±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | 0.1 M HCl: 1 mg/mL |
| form | solid |
| pka | -0.63±0.20(Predicted) |
| color | violet |
| CAS DataBase Reference | 91300-60-6(CAS DataBase Reference) |
Safety information for 6-ANILINO-5,8-QUINOLINEDIONE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 6-ANILINO-5,8-QUINOLINEDIONE
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