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HomeProduct name list6-ANILINO-5,8-QUINOLINEDIONE

6-ANILINO-5,8-QUINOLINEDIONE

Synonym(s):6-(Phenylamino)-5,8-quinolinedione;6-Anilino-5,8-quinolinequinone;LY 83583 - CAS 91300-60-6 - Calbiochem;LY-83,583;LY83583

6-ANILINO-5,8-QUINOLINEDIONE Structural

What is 6-ANILINO-5,8-QUINOLINEDIONE?

Chemical properties

Red-Brown Solid

The Uses of 6-ANILINO-5,8-QUINOLINEDIONE

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release

The Uses of 6-ANILINO-5,8-QUINOLINEDIONE

Inhibits nitric-oxide-induced activation of soluble guanylate cyclase (IC50=2μM) in a dose-dependent and reversible manner. It blocks acetylcholine induced vasorelaxation. Also an inhibitor of antigen-induced leukotriene release.

The Uses of 6-ANILINO-5,8-QUINOLINEDIONE

LY83583 is an inhibitor of soluble guanylate cyclase and of cGMP production. It inhibits soluble guanylate cyclase in human platelets with an IC50 value of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 value of 1.8 μM and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki value of 3 μM.[Cayman Chemical]

What are the applications of Application

LY 83583 is an inhibitor of guanylate cyclase

Definition

ChEBI: A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group.

Properties of 6-ANILINO-5,8-QUINOLINEDIONE

Melting point: 184-185°C
Boiling point: 446.9±45.0 °C(Predicted)
Density  1.400±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  0.1 M HCl: 1 mg/mL
form  solid
pka -0.63±0.20(Predicted)
color  violet
CAS DataBase Reference 91300-60-6(CAS DataBase Reference)

Safety information for 6-ANILINO-5,8-QUINOLINEDIONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 6-ANILINO-5,8-QUINOLINEDIONE

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