Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listNORTRIPTYLINE HYDROCHLORIDE

NORTRIPTYLINE HYDROCHLORIDE

Synonym(s):3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride;Desmethylamitriptyline hydrochloride;Nortriptyline hydrochloride

  • CAS NO.:894-71-3
  • Empirical Formula: C19H22ClN
  • Molecular Weight: 299.84
  • MDL number: MFCD00058024
  • EINECS: 212-973-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
NORTRIPTYLINE HYDROCHLORIDE Structural

What is NORTRIPTYLINE HYDROCHLORIDE?

Chemical properties

Off-White Solid

Originator

Aventyl,Lilly,UK,1963

The Uses of NORTRIPTYLINE HYDROCHLORIDE

Nortriptyline Hydrochloride (Amitriptyline EP Impurity C) is a tricyclic antidepressant.

The Uses of NORTRIPTYLINE HYDROCHLORIDE

Monoamine reuptake inhibitor; tricyclic antidepressant.

What are the applications of Application

Nortriptyline Hydrochloride is a 5-HT2 serotonin receptor antagonist

Definition

ChEBI: Nortriptyline hydrochloride is an organic tricyclic compound. It has a role as a geroprotector.

Manufacturing Process

A mixture of 114.5 g of 5-(3-chloropropylidene)dibenzo[a,d]cyclohepta[1,4] diene, 75 ml of benzene, and about 400 ml of methylamine is heated in an autoclave at 120°C for six hours. The excess methylamine is distilled from the reaction mixture under vacuum and the residue is stirred with 300 ml of water. Acidification of the mixture with hydrochloric acid causes the separation of the hydrochloride of 5-(3-methylaminopropylidene)dibenzo[a,d] cyclohepta[1,4]diene. The product is collected by filtration and is purified by recrystallization from a mixture of absolute ethanol and ethyl acetate. MP 210°C to 212°C.

brand name

Aventyl Hydrochloride (Lilly); Aventyl Hydrochloride (Ranbaxy); Pamelor (Tyco).

Therapeutic Function

Antidepressant

General Description

Pertinent biological and chemical properties for nortriptyline,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)Nmethyl-1-propanamine hydrochloride, 5-(3-methyl-aminopropylidene)-10,11-hydro-5H-dibenzo[a,d] cycloheptene hydrochloride(Aventyl, Pamelor), are given previously in thediscussion of amitriptyline. Metabolic inactivation and eliminationare like those of amitriptyline. Nortriptyline is a selectiveNE transporter (NET) inhibitor.

Biological Activity

ki: 3.4 nm: blocks the norepinephrine transporter.ki: 161 nm: inhibits the serotonin transporter.nortriptyline, a dibenzocycloheptene-derivative tricyclic antidepressant, inhibits norepinephrine and serotonin transporters, which is used for short-term treatment of various forms of depression, including major depression, dysthymia, and atypical depressions. nortriptyline suppresses the norepinephrine presynaptic receptors, thus inhibiting the reuptake of this neurotransmitter and increasing the concentration in the synaptic cleft in the central nervous system.norepinephrine transporter is responsible for the sodium-chloride (na+/cl-) -dependent reuptake of extracellular norepinephrine. serotonin transporter transports serotonin from the synaptic cleft to the presynaptic neuron.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.

in vitro

nortriptyline dose-dependently dampened the spontaneous migration of human polymorphonuclear cells (pmn) at the highest concentrations (10-4 and 10-5 m). nortriptyline decreased the motility of the cells at 10-4m. chemotaxis of pmn triggered by 10-10m n-formyl-l-methionil-l-leucyl-l-phenylalanine (fmlp) was blocked by nortriptyline in a dose-dependent fashion [1].

in vivo

rats and mice were injected intraperitoneally with nortriptyline at the dose of 50, 25, 12.5 mg/kg. after 2 hours of the last injection, nortriptyline inducted little or no inhibition of the 4, α-dimethyl-meta-tyramine (h 77/77) induced depletion in a dose of 25 + 12.5 mg/kg. however, there was a partial blockade, evoked by nortriptyline in a dose of 50 + 25 mg/kg, of the h 77/77 elicited depletion in the noradrenaline nerve terminals in all the rats studied. additionally, nortriptyline also proved to be active in the brain, however, its activity was low [2].

References

[1]. sacerdote, p., bianchi, m., & panerai, a. chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. general pharmacology: the vascular system. 1994; 25(3): 409-412.
[2]. carlsson, a., corrodi, h., fuxe, k., & hkfelt, t. effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4, α-dimethyl-meta-tyramine. european journal of pharmacology.1969; 5(4): 367-373.

Properties of NORTRIPTYLINE HYDROCHLORIDE

Melting point: 217-220?C
Flash point: 9℃
storage temp.  2-8°C
solubility  ethanol: 100 mg/mL
form  powder
color  white to off-white
λmax 237nm(H2O)(lit.)
Merck  14,6715

Safety information for NORTRIPTYLINE HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for NORTRIPTYLINE HYDROCHLORIDE

Abamectin manufacturer

R L Fine Chem Pvt. Ltd

1Y
Phone:+91-8042488999
product: Nortriptyline hydrochloride 98%
Inquiry

Centaur Pharmaceuticals Pvt Ltd

1Y
Phone:+912266499100
Whatsapp: +91 2266499100
product: Nortriptyline hydrochloride 894-71-3 99%
Inquiry

Vachichem

1Y
Phone:91-0-9880599557
Whatsapp: +91-9880599557
product: 894-71-3 Nortriptyline hydrochloride 98%
Inquiry

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: 894-71-3 98%
Inquiry

Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Nortriptyline hydrochloride 98%
Inquiry

THINQ Pharma CRO Ltd

1Y
Phone:+91-8879460113
Whatsapp: +91-8879460113
product: 894-71-3 99%
Inquiry

Ken Pharma

Maharashtra
product: Nortriptyline hydrochloride
Inquiry

Festiva Pharma

Gujarat
Phone:91-9033667967
Whatsapp: 91-9033667967
product: Nortriptyline hydrochloride
Inquiry

Related products of tetrahydrofuran

You may like

  • Nortriptyline Hydrochloride >95% CAS 894-71-3
    Nortriptyline Hydrochloride >95% CAS 894-71-3
    894-71-3
    View Details
  • Nortriptyline Hydrochloride CAS 894-71-3
    Nortriptyline Hydrochloride CAS 894-71-3
    894-71-3
    View Details
  • Nortriptyline hydrochloride CAS 894-71-3
    Nortriptyline hydrochloride CAS 894-71-3
    894-71-3
    View Details
  • Nortriptyline hydrochloride CAS 894-71-3
    Nortriptyline hydrochloride CAS 894-71-3
    894-71-3
    View Details
  • Nortriptyline Hydrochloride CAS 894-71-3
    Nortriptyline Hydrochloride CAS 894-71-3
    894-71-3
    View Details
  • Nortriptyline hydrochloride CAS 894-71-3
    Nortriptyline hydrochloride CAS 894-71-3
    894-71-3
    View Details
  • Nortriptyline hydrochloride solution CAS 894-71-3
    Nortriptyline hydrochloride solution CAS 894-71-3
    894-71-3
    View Details
  • Nortriptyline hydrochloride CAS 894-71-3
    Nortriptyline hydrochloride CAS 894-71-3
    894-71-3
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.