nooglutil
- CAS NO.:112193-35-8
- Empirical Formula: C11H12N2O6
- Molecular Weight: 268.22
- MDL number: MFCD00872338
- EINECS: 200-184-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-17 21:46:39
What is nooglutil?
The Uses of nooglutil
N-(5-hydroxynicotinoyl)-L-glutamic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
A solution of 233 g (5.83 mol) of NaOH in 930 mL of water was added to 345 g of the raw diethyl ester 15 ina 3-L one-neck flask, and the mixture was stirred a troom temperature for 2 h, after which 30 g of activated carbon was added, and stirring was continued for an additional 30 min and filtered on a Buchner funnel tor remove the activated carbon. The filtrate was made acidic (pH 4) by adding 545 mL of conc. HCl and stirred for 1 h. The precipitate was filtered off (Schott filter no. 3), washed with water (3 ?á 600 mL), suspended in 750 mL of water, acidified to pH 4 with 65 mL of conc. HCl, and immediately neutralized to pH 8 with 90 mL of 40% NaOH. Activated carbon, 13 g, was then added, and the mixture was stirred for 30 min, the activated carbon was removed by filtration, and the filtrate was acidified to pH 4 with conc. HCl. The precipitate was filtered off, washed with water (3 ?á 500 mL), and dried at 55 ??C and a vacuum of 40 mmHg for 12 h to obtain 129 g (70%) of the target product, purity by HPLC 99.61%, main substance content by titration 80% (water 21%).
Properties of nooglutil
Boiling point: | 704.7±60.0 °C(Predicted) |
Density | 1.514±0.06 g/cm3(Predicted) |
pka | 3.15±0.10(Predicted) |
Safety information for nooglutil
Computed Descriptors for nooglutil
New Products
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