Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listNolatrexed dihydrochloride

Nolatrexed dihydrochloride

  • CAS NO.:152946-68-4
  • Empirical Formula: C14H14Cl2N4OS
  • Molecular Weight: 357.26
  • MDL number: MFCD00917041
  • EINECS: 680-267-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
Nolatrexed dihydrochloride Structural

What is Nolatrexed dihydrochloride?

Chemical properties

Tan Solid

The Uses of Nolatrexed dihydrochloride

Antifolate thymidylate synthase inhibitor. Antineoplastic.

What are the applications of Application

Nolatrexed Dihydrochloride is an inhibitor of thymidylate synthase

Biological Activity

thymidylate synthase (ts) is a crucial enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for dna biosynthesis. thus, this enzyme is a critical target in cancer chemotherapy. nolatrexed (ag-337) is a non-classical thymidylate synthase inhibitor.

in vitro

nolatrexed was designed using x-ray crystallographic data from the ts molecular modeling and folate binding site. it is a non-classical ts inhibitor in that it lacks a terminal glutamate side chain and is uncharged at physiological ph. nolatrexed does not require a specific transport mechanism to enter into cells and, once within the cell, is not a substrate for the enzyme folyl polyglutamate synthetase [1].

in vivo

when nolatrexed was administered to nude mice bearing bu25tk- tumor xenografts, a time-dependent increase in antitumor activity was observed [1].

References

[1] hughes an, rafi i, griffin mj, calvert ah, newell dr, calvete ja, johnston a, clendeninn n, boddy av. phase i studies with the nonclassical antifolate nolatrexed dihydrochloride (ag337, thymitaq) administered orally for 5 days. clin cancer res. 1999 jan;5(1):111-8.
[2] rafi i, boddy av, calvete ja, taylor ga, newell dr, bailey np, lind mj, green m, hines j, johnstone a, clendeninn n, calvert ah. preclinical and phase i clinical studies with the nonclassical antifolate thymidylate synthase inhibitor nolatrexed dihydrochloride given by prolonged administration in patients with solid tumors. j clin oncol. 1998 mar;16(3):1131-41.

Properties of Nolatrexed dihydrochloride

Melting point: 301-3020C
storage temp.  Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility  Methanol, Water
form  Solid
pka 4.1; 5.9; 9.8(at 25℃)
color  Off-White to Pale Yellow
Stability: Hygroscopic
CAS DataBase Reference 152946-68-4(CAS DataBase Reference)

Safety information for Nolatrexed dihydrochloride

Computed Descriptors for Nolatrexed dihydrochloride

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.