N,N',N''-TRIACETYLCHITOTRIOSE
Synonym(s):NAG3;O-[2-Acetamido-2-deoxy-β-D -glucopyranosyl-(1→4)]-O-[2-acetamido-2-deoxy-β-D -glucopyranosyl-(1→4)]-2-acetamido-2-deoxy-D -glucopyranose;Tri(N-acetyl-D -glucosamine)
- CAS NO.:38864-21-0
- Empirical Formula: C24H41N3O16
- Molecular Weight: 627.59
- MDL number: MFCD00136047
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:38
What is N,N',N''-TRIACETYLCHITOTRIOSE?
Chemical properties
Off-White Crystalline Solid
The Uses of N,N',N''-TRIACETYLCHITOTRIOSE
N,N',N''-Triacetylchitotriose is a triose oligosaccharide derived from chitin, consisting of three N-acetylglucosamine units. It has been shown to scavenge reactive oxygen species and to protect DNA from oxidative damage.
The Uses of N,N',N''-TRIACETYLCHITOTRIOSE
N,N’,N’’-Triacetyl Chitotriose is a multivalent glycosides with strong crosslinking activity for lectin as a specific coagulant.
What are the applications of Application
N,N′,N′′-Triacetylchitotriose is an N-acetylglucosamine oligosaccharide
Definition
ChEBI: Tri-N-acetylchitotriose is a N-acyl-hexosamine.
Reactions
The hydrolytic activity of lysozyme towards 4-methylumbelliferyl tetra-N-acetyl-β-chitotetraoside (4-MU-(GlcNAc)4) was little affected by ionic strength, though the activity of lysozyme towards cell suspension of Micrococcus lysodeikticus varied markedly with ionic strength. About 40-60percent of lysozyme activity with 4-MU-(GlcNAc)4 as a substrate was inhibited by 0.1 mM N,N',N''-triacetylchitotriose ((GlcNAc)3), but the lytic activity of lysozyme towards M. lysodeikticus was little affected. The kinetics of hydrolysis of 4-MU-(GlcNAc)4 by hen eggwhite (HEW) lysozyme and human placental (HP) lysozyme and the inhibition of this hydrolysis by (GlcNAc)3 were investigated. The K(s) values for 4-MU-(GlcNAc)4 of HEW- and HP-lysozymes were 19.7 and 27.9 μM, respectively, and the V(max) values were 0.124 and 0.0833 nmol/min/mg, respectively. The k values of both enzymes were very low, implying a poor orientation of the scissile bond in the substrate molecule with respect to the active site of lysozyme. (GlcNAc)3 inhibited lysozyme with hyperbolic mixed-type inhibition. The inhibition reduced V(max) values of both lysozymes. The K(s) value of HEW-lysozyme was increased by the addition of the inhibitory whereas the K(s) value of HP-lysozyme was decreased. The K(i) value was 29.6 μm for HEW-lysozyme and 106 μM for HP-lysozyme.
- Hydrolysis of 4-methylumbelliferyl tetra-N-acetyl-β-chitotetraoside by lysozyme and its inhibition by N,N',N''-triacetylchitotriose
- Tanimoto; Fukuda; Kawamura - Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 9, p. 3607 - 361
Properties of N,N',N''-TRIACETYLCHITOTRIOSE
Melting point: | 271-272°C dec. |
Boiling point: | 1146.9±65.0 °C(Predicted) |
Density | 1.54±0.1 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | H2O: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow |
pka | 12.72±0.70(Predicted) |
form | Solid |
color | White to Pale Beige |
BRN | 75249 |
Safety information for N,N',N''-TRIACETYLCHITOTRIOSE
Computed Descriptors for N,N',N''-TRIACETYLCHITOTRIOSE
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