N-Hydroxyethylphthalimide
Synonym(s):2-Phthalimidoethanol
- CAS NO.：3891-07-4
- Empirical Formula: C10H9NO3
- Molecular Weight: 191.18
- MDL number: MFCD00005903
- EINECS: 223-434-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-29 15:17:36
What is N-Hydroxyethylphthalimide?
Chemical properties
white crystalline powder
The Uses of N-Hydroxyethylphthalimide
N-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 4, p. 106, 1963
The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601
General Description
N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides.
Properties of N-Hydroxyethylphthalimide
| Melting point: | 126-128 °C(lit.) |
| Boiling point: | 326.92°C (rough estimate) |
| Density | 1.2722 (rough estimate) |
| refractive index | 1.5310 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 14.40±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| BRN | 147214 |
| CAS DataBase Reference | 3891-07-4(CAS DataBase Reference) |
| NIST Chemistry Reference | N-2-hydroxyethyl phthalimide(3891-07-4) |
| EPA Substance Registry System | 1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- (3891-07-4) |
Safety information for N-Hydroxyethylphthalimide
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for N-Hydroxyethylphthalimide
| InChIKey | MWFLUYFYHANMCM-UHFFFAOYSA-N |
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product: Phthalimido ethanol 3891-07-4 98%
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