N,N-Diethylformamide

Synonym(s):Formic acid diethylamide;N,N-Diethylformamide

CAS NO.：617-84-5
Empirical Formula: C5H11NO
Molecular Weight: 101.15
MDL number: MFCD00003287
EINECS: 210-533-2
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is N,N-Diethylformamide?

Chemical properties

clear colorless to pale yellow liquid

The Uses of N,N-Diethylformamide

N,N-Diethylformamide is used in the synthesis of metal-organic frameworks and Diethyltrifluoromethylamine. It is also used as solvent in the preparation of porous cubic-shaped zinc oxide particles. It is involved in the preparation of quinazoline-2,4(1H,3H)-dione by reacting with o-aminonitrile.

The Uses of N,N-Diethylformamide

N,N-Diethylformamide was used in the synthesis of metal-organic frameworks. It was also used as solvent in the synthesis of porous cubic-shaped ZnO particles.

Definition

ChEBI: N,N-diethyl-Formamide is a carboxamide.

General Description

N,N-Diethylformamide undergoes condensation with aromatic o-aminonitriles in the presence of ZnCl₂ in sealed reactor to yield quinazoline-2,4(1H,3H)-dione.

Properties of N,N-Diethylformamide

Melting point:	176-177°C
Boiling point:	176-177 °C (lit.)
Density	0.908 g/mL at 25 °C (lit.)
refractive index	n20/D 1.434(lit.)
Flash point:	141 °F
storage temp.	Store below +30°C.
solubility	Miscible with acetone, benzene, alcohol and ether.
form	Liquid
pka	-0.44±0.70(Predicted)
color	Clear colorless to pale yellow
BRN	1209392
Dielectric constant	29.02
CAS DataBase Reference	617-84-5(CAS DataBase Reference)
EPA Substance Registry System	Formamide, N,N-diethyl- (617-84-5)

Safety information for N,N-Diethylformamide

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.