N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide

Synonym(s):N,N′-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide;N,N′-Bis(2,3-dihydroxypropyl)-5-nitroisophthalamide

CAS NO.：76820-34-3
Empirical Formula: C14H19N3O8
Molecular Weight: 357.32
MDL number: MFCD06657564
EINECS: 616-392-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-27 16:27:43

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide Structural

What is N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide?

Description

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is a non-ionic organic compound that can be used as a reaction intermediate for the preparation of amidated iodinated x-ray contrast media. The amidation reaction is typically carried out in aqueous solution with an acid catalyst at room temperature for up to 24 hours. The amidation reaction condition and time can be optimized depending on the desired end product. Industrial preparation of iohexol typically involves the use of an x-ray generator and iopamidol, which is synthesized from diethylene triamine and ethylenediamine.

Chemical properties

White to Off-White Solid.

The Uses of N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide

N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide is used in the preparation of X-ray contrast agents.

Properties of N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide

Melting point:	>140°C (dec.)
Density	1.347 at 20℃
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form	Solid
color	White to Off-White
Stability:	Hygroscopic
CAS DataBase Reference	76820-34-3(CAS DataBase Reference)

Safety information for N,N'-Bis(2,3-dihydroxypropyl)-5-nitro-1,3-benzenedicarboxamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.